| UniProt/SwissProt ID: | PI51C_HUMAN |
| Description: | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [Source:HGNC Symbol;Acc:8996] |
| Location: | chr19 p13.3 |
| Node attribute: | PPI(source); Enzyme(source); Enzyme(target); substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S650 | RSWVYsPLHYS | CDK5 | HPRD |
| Y649 | ERSWVySPLHY | CSK | RegPhos |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S650 | DERSWVYsPLHYSAQ | HPRD | |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000335333 | S534F | COSMIC | Melanoma | 21499247 | ENSP00000335333 | R304W | COSMIC | Gastric Cancer | 21097718 | ENSP00000335333 | L652F | COSMIC | Gastric Cancer | 21097718 |
| Differential expressed protein |
| PI51C_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PI51C_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK_HUMAN | PI51C_HUMAN | kinase -> substrate | RegPhos |
| CDK5_HUMAN | PI51C_HUMAN | kinase -> substrate | HPRD |
| PI3R5_HUMAN | PI51C_HUMAN | enzyme catalysis | KEGG |
| PI51C_HUMAN | PI4KA_HUMAN | enzyme catalysis | KEGG |
| PLCD3_HUMAN | PI51C_HUMAN | enzyme catalysis | KEGG |
| PI51C_HUMAN | PI3R5_HUMAN | enzyme catalysis | KEGG |
| PI51C_HUMAN | PLCD3_HUMAN | enzyme catalysis | KEGG |
| PI51C_HUMAN | PTEN_HUMAN | enzyme catalysis | KEGG |
| PI51C_HUMAN | I5P2_HUMAN | enzyme catalysis | KEGG |
| PI51C_HUMAN | MTM1_HUMAN | enzyme catalysis | KEGG |
| PTEN_HUMAN | PI51C_HUMAN | enzyme catalysis | KEGG |
| PI51C_HUMAN | PI42A_HUMAN | enzyme catalysis | KEGG |
| PI51C_HUMAN | VINC_HUMAN | other | KEGG |
| PI51C_HUMAN | ACTG_HUMAN | other | KEGG |
| RHOA_HUMAN | PI51C_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00562 | Inositol phosphate metabolism |
| hsa04510 | Focal adhesion |
| hsa01100 | Metabolic pathways |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04144 | Endocytosis |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa04070 | Phosphatidylinositol signaling system |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0034333 | adherens junction assembly | TAS | biological_process |
| GO:0006909 | phagocytosis | TAS | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0016079 | synaptic vesicle exocytosis | TAS | biological_process |
| GO:0072583 | clathrin-mediated endocytosis | TAS | biological_process |
| GO:0001891 | phagocytic cup | IEA | cellular_component |
| GO:0016337 | cell-cell adhesion | TAS | biological_process |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0016307 | phosphatidylinositol phosphate kinase activity | IEA | molecular_function |
| GO:0006644 | phospholipid metabolic process | TAS | biological_process |
| GO:0048488 | synaptic vesicle endocytosis | TAS | biological_process |
| GO:0007409 | axonogenesis | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activi | IEA | molecular_function |
| GO:0030036 | actin cytoskeleton organization | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005925 | focal adhesion | TAS | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0032587 | ruffle membrane | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0030593 | neutrophil chemotaxis | TAS | biological_process |
| GO:0046488 | phosphatidylinositol metabolic process | IEA | biological_process |
| GO:0001931 | uropod | TAS | cellular_component |
| GO:0012505 | endomembrane system | IEA | cellular_component |