| UniProt/SwissProt ID: | RAD51_HUMAN |
| Description: | RAD51 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:9817] |
| Location: | chr15 q15.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T309 | KGRGEtRICKI | phosphoELM; RegPhos | |
| Y315 | RICKIyDSPCL | Abl | phosphoELM |
| Y315 | RICKIyDSPCL | ABL1 | HPRD; RegPhos |
| T13 | EANADtSVEEE | PhosphoSitePlus | |
| Y54 | VEAVAyAPKKE | ABL1 | HPRD; RegPhos |
| T309 | KGRGEtRICKI | CHK1 | RegPhos |
| S14 | ANADTsVEEES | PhosphoSitePlus | |
| Y301 | STTRLyLRKGR | Rad51 | PhosphoSitePlus |
| Y315 | RICKIyDSPCL | Rad51 | PhosphoSitePlus |
| Y54 | VEAVAyAPKKE | Abl | phosphoELM |
| Y54 | VEAVAyAPKKE | HhH-GPD | PhosphoSitePlus |
| T309 | KGRGEtRICKI | Rad51 | PhosphoSitePlus |
| T309 | KGRGEtRICKI | CHEK1 | HPRD |
| Dephosphorylation site |
| RAD51_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000267868 | Q145* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000433924 | Q146* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000267868 | R150Q | OMIM, HPI | Breast Cancer | 10807537, 10807537 17666788 16762046 | ENSP00000372088 | Q146* | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| RAD51_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RAD51_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ABL1_HUMAN | RAD51_HUMAN | kinase -> substrate | RegPhos |
| CHK1_HUMAN | RAD51_HUMAN | kinase -> substrate | HPRD; RegPhos |
| MK01_HUMAN | RAD51_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK4_HUMAN | RAD51_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | RAD51_HUMAN | kinase -> substrate | RegPhos |
| CDKL5_HUMAN | RAD51_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | RAD51_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | RAD51_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AAPK1_HUMAN | RAD51_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03460 | Fanconi anemia pathway |
| hsa05200 | Pathways in cancer |
| hsa03440 | Homologous recombination |
| hsa05212 | Pancreatic cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006259 | DNA metabolic process | IEA | biological_process |
| GO:0007131 | reciprocal meiotic recombination | TAS | biological_process |
| GO:0000794 | condensed nuclear chromosome | IEA | cellular_component |
| GO:0000724 | double-strand break repair via homologous recombin | IEA | biological_process |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0051260 | protein homooligomerization | IPI | biological_process |
| GO:0051106 | positive regulation of DNA ligation | IDA | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006312 | mitotic recombination | TAS | biological_process |
| GO:0017111 | nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0000793 | condensed chromosome | IEA | cellular_component |
| GO:0006302 | double-strand break repair | TAS | biological_process |
| GO:0003690 | double-stranded DNA binding | IDA | molecular_function |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0000794 | condensed nuclear chromosome | ISS | cellular_component |
| GO:0006310 | DNA recombination | TAS | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0000800 | lateral element | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0043142 | single-stranded DNA-dependent ATPase activity | IDA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000730 | DNA recombinase assembly | TAS | biological_process |
| GO:0008094 | DNA-dependent ATPase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0007126 | meiosis | IEA | biological_process |
| GO:0005759 | mitochondrial matrix | IEA | cellular_component |
| GO:0000793 | condensed chromosome | ISS | cellular_component |
| GO:0006268 | DNA unwinding involved in replication | IDA | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0003684 | damaged DNA binding | IEA | molecular_function |
| GO:0003697 | single-stranded DNA binding | IDA | molecular_function |
| GO:0005634 | nucleus | ISS | cellular_component |
| GO:0009432 | SOS response | IEA | biological_process |