| UniProt/SwissProt ID: | WASF1_HUMAN |
| Description: | WAS protein family, member 1 [Source:HGNC Symbol;Acc:12732] |
| Location: | chr6 q21 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S91 | KEEELsLQDIT | PhosphoSitePlus; HPRD | |
| S489 | PKRHPsTLPVI | PhosphoSitePlus | |
| Y125 | PLQETyDVCEQ | Src | RegPhos |
| S339 | ALSTSsLRASM | PhosphoSitePlus | |
| S441 | GIRPSsPVTVT | CDK5 | HPRD |
| S397 | PLVQPsPPVAR | CDK5 | HPRD |
| Y125 | PLQETyDVCEQ | SRC | phosphoELM |
| Y125 | PLQETyDVCEQ | PhosphoSitePlus | |
| S298 | IPTCIsSATGL | HPRD | |
| T490 | KRHPStLPVIS | PhosphoSitePlus | |
| S310 | ENRPQsPATGR | PhosphoSitePlus | |
| S310 | ENRPQsPATGR | CDK5 | HPRD |
| T96 | SLQDItMRKAF | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| WASF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376365 | Q110* | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| WASF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| WASF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK5_HUMAN | WASF1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04520 | Adherens junction |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa05132 | Salmonella infection |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05131 | Shigellosis |
| hsa05100 | Bacterial invasion of epithelial cells |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0015629 | actin cytoskeleton | TAS | cellular_component |
| GO:0005741 | mitochondrial outer membrane | IEA | cellular_component |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0030041 | actin filament polymerization | TAS | biological_process |
| GO:0030027 | lamellipodium | IEA | cellular_component |
| GO:0005856 | cytoskeleton | TAS | cellular_component |
| GO:0006461 | protein complex assembly | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003779 | actin binding | IEA | molecular_function |