UniProt/SwissProt ID: | GBB2_HUMAN |
Description: | guanine nucleotide binding protein (G protein), beta polypeptide 2 [Source:HGNC Symbol;Acc:4398] |
Location: | chr7 q22.1 |
Node attribute: | Gprotein |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S2 | LEQL | HPRD | |
S2 | ____MsELEQL | PhosphoSitePlus | |
Y239 | FFPNGyAFTTG | WD40 | PhosphoSitePlus |
Dephosphorylation site |
GBB2_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000305260 | M101T | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000377503 | M101T | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000377501 | M101T | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000377503 | M101T | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000305260 | M101T | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000377501 | M101T | TCGA | Ovarian Cancer | 21720365, 18772890 |
Differential expressed protein |
Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
---|---|---|---|---|---|---|
ENSP00000377501 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 3.8 | 18715028 |
ENSP00000377501 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Up | 39 | 16319398 |
ENSP00000377501 | Gastric Cancer | Treatment (none vs. Vincristine-resistant) | cell line | Down | 16525997 | |
ENSP00000377501 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Down | 0.59 | 20625496 |
Hyperphosphorylation site |
GBB2_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
GBB2_HUMAN | TBG2_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK12_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | PLCB2_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK10_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | ADCY7_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RAF1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | KPCD1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHOA_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | ARBK2_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK6_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RAC3_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK11_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | ADCY2_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBA3C_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RAC2_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBD_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | CAC1A_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | CALL3_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHOC_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBA1B_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | PK3CG_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBA1C_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBB4B_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBB6_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RGRF1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | KSR1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | ADCY1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | ITK_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | CAC1B_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | PLCB3_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHOD_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBA4B_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBA1A_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBB2A_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBB8_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | SHC2_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBA3E_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | CALM_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBE_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | ADCY4_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | PLCB1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | PK3CB_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | ARBK1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RND3_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBB4A_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | DYN1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RND2_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBB3_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBB1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | SHC1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHOF_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK8_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RAC1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBB5_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHBT1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | BTK_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHOQ_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | PK3CA_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHOG_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | CALL6_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | CALL5_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RND1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHOJ_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK3_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK14_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK9_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBA4A_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBG1_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBA8_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | IRK5_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | TBAL3_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | RHOB_HUMAN | Gprotein -> effector | gpDB |
GBB2_HUMAN | CALL4_HUMAN | Gprotein -> effector | gpDB |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04728 | Dopaminergic synapse |
hsa04727 | GABAergic synapse |
hsa04723 | Retrograde endocannabinoid signaling |
hsa04725 | Cholinergic synapse |
hsa04726 | Serotonergic synapse |
hsa05034 | Alcoholism |
hsa04062 | Chemokine signaling pathway |
hsa04724 | Glutamatergic synapse |
hsa05032 | Morphine addiction |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0005515 | protein binding | IEA | molecular_function |
GO:0043234 | protein complex | IEA | cellular_component |
GO:0005886 | plasma membrane | TAS | cellular_component |
GO:0005246 | calcium channel regulator activity | IEA | molecular_function |
GO:0007268 | synaptic transmission | TAS | biological_process |
GO:0071377 | cellular response to glucagon stimulus | TAS | biological_process |
GO:0006112 | energy reserve metabolic process | TAS | biological_process |
GO:0051020 | GTPase binding | IPI | molecular_function |
GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
GO:0044281 | small molecule metabolic process | TAS | biological_process |
GO:0003924 | GTPase activity | TAS | molecular_function |
GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
GO:0004871 | signal transducer activity | IEA | molecular_function |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0006184 | GTP catabolic process | TAS | biological_process |
GO:0044297 | cell body | IEA | cellular_component |