Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GBB2_HUMAN
Description:guanine nucleotide binding protein (G protein), beta polypeptide 2 [Source:HGNC Symbol;Acc:4398]
Location:chr7 q22.1
Node attribute:Gprotein

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2LEQLHPRD
S2____MsELEQLPhosphoSitePlus
Y239FFPNGyAFTTGWD40PhosphoSitePlus

Dephosphorylation site
GBB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000305260M101TCOSMICOvarian Cancer21720365
ENSP00000377503M101TTCGAOvarian Cancer21720365, 18772890
ENSP00000377501M101TCOSMICOvarian Cancer21720365
ENSP00000377503M101TCOSMICOvarian Cancer21720365
ENSP00000305260M101TTCGAOvarian Cancer21720365, 18772890
ENSP00000377501M101TTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000377501hepatitis C virusNormal vs. CancertissueUp3.818715028
ENSP00000377501Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp3916319398
ENSP00000377501Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineDown16525997
ENSP00000377501Gastric CancerTreatment (none vs. drug-resistant)cell lineDown0.5920625496

Hyperphosphorylation site
GBB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBB2_HUMANTBG2_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBB2_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK10_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY7_HUMANGprotein -> effectorgpDB
GBB2_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBB2_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOH_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOA_HUMANGprotein -> effectorgpDB
GBB2_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK6_HUMANGprotein -> effectorgpDB
GBB2_HUMANRAC3_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK11_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA3C_HUMANGprotein -> effectorgpDB
GBB2_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBD_HUMANGprotein -> effectorgpDB
GBB2_HUMANCAC1A_HUMANGprotein -> effectorgpDB
GBB2_HUMANCALL3_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOC_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBB2_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA1C_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB6_HUMANGprotein -> effectorgpDB
GBB2_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBB2_HUMANSHC3_HUMANGprotein -> effectorgpDB
GBB2_HUMANKSR1_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY1_HUMANGprotein -> effectorgpDB
GBB2_HUMANITK_HUMANGprotein -> effectorgpDB
GBB2_HUMANCAC1B_HUMANGprotein -> effectorgpDB
GBB2_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB2B_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOD_HUMANGprotein -> effectorgpDB
GBB2_HUMANCAC1E_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA4B_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK15_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB2A_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB8_HUMANGprotein -> effectorgpDB
GBB2_HUMANSHC2_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA3E_HUMANGprotein -> effectorgpDB
GBB2_HUMANCALM_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBE_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY4_HUMANGprotein -> effectorgpDB
GBB2_HUMANPLCB1_HUMANGprotein -> effectorgpDB
GBB2_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBB2_HUMANARBK1_HUMANGprotein -> effectorgpDB
GBB2_HUMANRND3_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB4A_HUMANGprotein -> effectorgpDB
GBB2_HUMANDYN1_HUMANGprotein -> effectorgpDB
GBB2_HUMANRND2_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBB2_HUMANSHC1_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOF_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBB2_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHBT1_HUMANGprotein -> effectorgpDB
GBB2_HUMANBTK_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOQ_HUMANGprotein -> effectorgpDB
GBB2_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOG_HUMANGprotein -> effectorgpDB
GBB2_HUMANCALL6_HUMANGprotein -> effectorgpDB
GBB2_HUMANCALL5_HUMANGprotein -> effectorgpDB
GBB2_HUMANRND1_HUMANGprotein -> effectorgpDB
GBB2_HUMANDNM1L_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOJ_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK14_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK9_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBG1_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA8_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK5_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHBT2_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBAL3_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBB2_HUMANCALL4_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04728Dopaminergic synapse
hsa04727GABAergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa05034Alcoholism
hsa04062Chemokine signaling pathway
hsa04724Glutamatergic synapse
hsa05032Morphine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0043234protein complexIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005246calcium channel regulator activityIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0051020GTPase bindingIPImolecular_function
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006184GTP catabolic processTASbiological_process
GO:0044297cell bodyIEAcellular_component