Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADCY2_HUMAN
Description:adenylate cyclase 2 (brain) [Source:HGNC Symbol;Acc:233]
Location:chr5 p15.31
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S472KGERRsPQHLFPhosphoSitePlus
Y584ISLLFyNKVLEDUF1053PhosphoSitePlus
Y282NFHNLyVKRHTGuanylate_cycPhosphoSitePlus

Dephosphorylation site
ADCY2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000342952M530ICOSMICOvarian Cancer21720365
ENSP00000342952H533DCOSMICOvarian Cancer21720365
ENSP00000342952V888ICOSMICOvarian Cancer21720365
ENSP00000342952M530ITCGAOvarian Cancer21720365, 18772890
ENSP00000342952S752FCOSMICMelanoma21499247
ENSP00000342952V888ITCGAOvarian Cancer21720365, 18772890
ENSP00000342952V72FCOSMICOvarian Cancer21720365
ENSP00000342952H533DTCGAOvarian Cancer21720365, 18772890
ENSP00000342952R301WBIOMARTBreast Cancer21930507, 21930502
ENSP00000342952A87.0VBIOMARTBrain Cancer21930507, 21930502
ENSP00000342952R238HCOSMICOvarian Cancer21720365

Differential expressed protein
ADCY2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADCY2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAS2_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBB3_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBG12_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBG3_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBG8_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBG11_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBG5_HUMANADCY2_HUMANGprotein -> effectorgpDB
GNAS1_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBB5_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBG13_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBG1_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBG2_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBG10_HUMANADCY2_HUMANGprotein -> effectorgpDB
GBB1_HUMANADCY2_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04723Retrograde endocannabinoid signaling
hsa04114Oocyte meiosis
hsa05414Dilated cardiomyopathy
hsa04727GABAergic synapse
hsa04971Gastric acid secretion
hsa04970Salivary secretion
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04062Chemokine signaling pathway
hsa04916Melanogenesis
hsa04976Bile secretion
hsa04540Gap junction
hsa04724Glutamatergic synapse
hsa05032Morphine addiction
hsa04270Vascular smooth muscle contraction
hsa04972Pancreatic secretion
hsa00230Purine metabolism
hsa04020Calcium signaling pathway
hsa05166HTLV-I infection
hsa04725Cholinergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031683G-protein beta/gamma-subunit complex bindingIEAmolecular_function
GO:0007193adenylate cyclase-inhibiting G-protein coupled recTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0016020membraneISScellular_component
GO:0008294calcium- and calmodulin-responsive adenylate cyclaIEAmolecular_function
GO:0004016adenylate cyclase activityISSmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0030425dendriteIEAcellular_component
GO:0016021integral to membraneNAScellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0006171cAMP biosynthetic processIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0007189adenylate cyclase-activating G-protein coupled recTASbiological_process
GO:0008179adenylate cyclase bindingIEAmolecular_function
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0006833water transportTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0055085transmembrane transportTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0006171cAMP biosynthetic processISSbiological_process
GO:0046872metal ion bindingIEAmolecular_function


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