| UniProt/SwissProt ID: | RHOH_HUMAN |
| Description: | ras homolog family member H [Source:HGNC Symbol;Acc:686] |
| Location: | chr4 p14 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S13 | VLVGDsAVGKT | Ras | PhosphoSitePlus |
| Dephosphorylation site |
| RHOH_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000371219 | R23H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000425010 | R23H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000371219 | R23H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000425010 | R23H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000371219 | G49S | COSMIC | Lung Cancer | 20668451 | ENSP00000425010 | G49S | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| RHOH_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RHOH_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBB2_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBG12_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBG10_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | RHOH_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04670 | Leukocyte transendothelial migration |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0030217 | T cell differentiation | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0017048 | Rho GTPase binding | NAS | molecular_function |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB c | IDA | biological_process |
| GO:0001772 | immunological synapse | IEA | cellular_component |
| GO:0045576 | mast cell activation | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005095 | GTPase inhibitor activity | NAS | molecular_function |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0042326 | negative regulation of phosphorylation | IDA | biological_process |
| GO:0019210 | kinase inhibitor activity | IDA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |