Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRK12_HUMAN
Description:potassium inwardly-rectifying channel, subfamily J, member 12 [Source:HGNC Symbol;Acc:6258]
Location:chrHG987_PATCH p11.2
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S64NMDEKsQRYLAIRKPhosphoSitePlus
S431PYRREsPRKACAHPRD
T354YEVPStPRCSAIRKPhosphoSitePlus
S405SRDGLsPQARHPhosphoSitePlus; HPRD; phosphoELM
T38NGKVHtRRRCRIRK_NPhosphoSitePlus

Dephosphorylation site
IRK12_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000328150E334DBIOMARTBrain Cancer21930507, 21930502
ENSP00000328150E154KCOSMICMelanoma21499247
ENSP00000328150R356HTCGAOvarian Cancer21720365, 18772890
ENSP00000328150S343LCOSMICOvarian Cancer21720365
ENSP00000328150I295NBIOMARTBreast Cancer21930507, 21930502
ENSP00000328150R356HCOSMICOvarian Cancer21720365
ENSP00000328150R229GCOSMICSkin Cancer21984974
ENSP00000328150P235LCOSMICSkin Cancer21984974
ENSP00000328150E378KBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000328150*434YCOSMICOvarian Cancer20826764
ENSP00000328150S343LTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
IRK12_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRK12_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG8_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBG13_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBB5_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBG1_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBG5_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBG12_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBG3_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBG10_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBG2_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBB1_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBB3_HUMANIRK12_HUMANGprotein -> effectorgpDB
GBG11_HUMANIRK12_HUMANGprotein -> effectorgpDB
KPCA_HUMANIRK12_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04725Cholinergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006813potassium ion transportTASbiological_process
GO:0015459potassium channel regulator activityTASmolecular_function
GO:0006936muscle contractionTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007268synaptic transmissionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008200ion channel inhibitor activityTASmolecular_function
GO:0005242inward rectifier potassium channel activityIEAmolecular_function
GO:0008015blood circulationNASbiological_process
GO:0008016regulation of heart contractionTASbiological_process


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