Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITK_HUMAN
Description:IL2-inducible T-cell kinase [Source:HGNC Symbol;Acc:6171]
Location:chr5 q33.3
Node attribute:kinase; effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y180VVIALyDYQTNSH3_1PhosphoSitePlus
Y180VVIALyDYQTNHPRD; RegPhos
T141LEKLAtGCAQYBTKPhosphoSitePlus
Y512VLDDQyTSSTGphosphoELM
T513LDDQYtSSTGTPkinase_TyrPhosphoSitePlus
Y225YVPSSyLVEKSPhosphoSitePlus
Y273RTAGTyTVSVFSH2PhosphoSitePlus
T274TAGTYtVSVFTSH2PhosphoSitePlus
T184LYDYQtNDPQESH3_1PhosphoSitePlus
T236PNNLEtYEWYNPhosphoSitePlus
S515DQYTSsTGTKFPkinase_TyrPhosphoSitePlus
T160KPLPPtPEDNRPhosphoSitePlus
S115TRNNNsLVPKYPhosphoSitePlus
S276GTYTVsVFTKASH2PhosphoSitePlus
Y512VLDDQyTSSTGautocatalysisRegPhos
S223EGYVPsSYLVESH3_1PhosphoSitePlus
Y237NNLETyEWYNKPhosphoSitePlus
S565ENRSNsEVVEDITKHPRD
S565ENRSNsEVVEDPkinase_TyrPhosphoSitePlus
Y512VLDDQyTSSTGLckphosphoELM; RegPhos
Y512VLDDQyTSSTGLCKHPRD; RegPhos
Y588ASTHVyQIMNHPkinase_TyrPhosphoSitePlus
Y90DNYLLyVFAPDPHPhosphoSitePlus
Y180VVIALyDYQTNBTKphosphoELM; RegPhos
Y353TAGLRyGKWVIPhosphoSitePlus
Y180VVIALyDYQTNITKphosphoELM; RegPhos
Y336VTRLRyPVCFGPhosphoSitePlus
T516QYTSStGTKFPPkinase_TyrPhosphoSitePlus
Y120SLVPKyHPNFWBTKPhosphoSitePlus
S565ENRSNsEVVEDphosphoELM; RegPhos
Y146TGCAQyDPTKNBTKPhosphoSitePlus
S514DDQYTsSTGTKPkinase_TyrPhosphoSitePlus
S203YCLLDsSEIHWSH3_1PhosphoSitePlus
Y40KASLAyFEDRHPHPhosphoSitePlus
Y198RRNEEyCLLDSSH3_1PhosphoSitePlus
T585PRLAStHVYQIPkinase_TyrPhosphoSitePlus
Y182IALYDyQTNDPSH3_1PhosphoSitePlus
T518TSSTGtKFPVKPkinase_TyrPhosphoSitePlus
Y220NGHEGyVPSSYSH3_1PhosphoSitePlus
T50HGKKRtLKGSIPHPhosphoSitePlus
S22QKRRTsPSNFKPHPhosphoSitePlus
Y512VLDDQyTSSTGPkinase_TyrPhosphoSitePlus

Dephosphorylation site
ITK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000398655E108QTCGAOvarian Cancer21720365, 18772890
ENSP00000398655D202ATCGAOvarian Cancer21720365, 18772890
ENSP00000398655A349STCGAOvarian Cancer21720365, 18772890
ENSP00000398655P159LTCGAOvarian Cancer21720365, 18772890
ENSP00000398655L582VTCGAOvarian Cancer21720365, 18772890
ENSP00000398655R451QHPIGastric Cancer17344846
ENSP00000398655A261PTCGAOvarian Cancer21720365, 18772890
ENSP00000398655A249PBIOMARTBreast Cancer21930507, 21930502
ENSP00000398655K119EBIOMARTchronic lymphocytic leukemia21930507, 21930502

Differential expressed protein
ITK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ITK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG1_HUMANITK_HUMANGprotein -> effectorgpDB
GBB1_HUMANITK_HUMANGprotein -> effectorgpDB
GBG11_HUMANITK_HUMANGprotein -> effectorgpDB
GBB3_HUMANITK_HUMANGprotein -> effectorgpDB
GBG10_HUMANITK_HUMANGprotein -> effectorgpDB
GBG3_HUMANITK_HUMANGprotein -> effectorgpDB
GBB5_HUMANITK_HUMANGprotein -> effectorgpDB
GBB2_HUMANITK_HUMANGprotein -> effectorgpDB
GBG8_HUMANITK_HUMANGprotein -> effectorgpDB
GBG2_HUMANITK_HUMANGprotein -> effectorgpDB
GBG13_HUMANITK_HUMANGprotein -> effectorgpDB
GBG5_HUMANITK_HUMANGprotein -> effectorgpDB
GBG12_HUMANITK_HUMANGprotein -> effectorgpDB
ITK_HUMANBMX_HUMANkinase -> substrateRegPhos
ITK_HUMANCD28_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LCK_HUMANITK_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
BTK_HUMANITK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ITK_HUMANVAV3_HUMANkinase -> substrateKEGG
ITK_HUMANITK_HUMANkinase -> substrateHPRD; RegPhos
ITK_HUMANLAT_HUMANkinase -> substrateNetPath
ITK_HUMANPLCG2_HUMANkinase -> substrateNetPath
ITK_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
ITK_HUMANBTK_HUMANkinase -> substrateHPRD; RegPhos
ITK_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
ITK_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
ITK_HUMANSIG10_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ITK_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANITK_HUMANkinase -> substrateRegPhos
ITK_HUMANPLCG1_HUMANkinase -> substrateNetPath
ITK_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
ITK_HUMANTEC_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ITK_HUMANKC1G2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005543phospholipid bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0032633interleukin-4 productionIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0001816cytokine productionISSbiological_process
GO:0032609interferon-gamma productionIEAbiological_process
GO:0007202activation of phospholipase C activityISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001865NK T cell differentiationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0050852T cell receptor signaling pathwayISSbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0006968cellular defense responseTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0042110T cell activationTASbiological_process
GO:0002250adaptive immune responseISSbiological_process
GO:0006468protein phosphorylationIEAbiological_process


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