| UniProt/SwissProt ID: | RHBT2_HUMAN |
| Description: | Rho-related BTB domain containing 2 [Source:HGNC Symbol;Acc:18756] |
| Location: | chr8 p21.3 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y432 | RAVLKyLYTGE | BTB | PhosphoSitePlus |
| T376 | LRGNGtGYLPG | PhosphoSitePlus | |
| S388 | GRVLSsWSRAF | BTB | PhosphoSitePlus |
| Y434 | VLKYLyTGELD | BTB | PhosphoSitePlus |
| T435 | LKYLYtGELDE | BTB | PhosphoSitePlus |
| S390 | VLSSWsRAFVS | BTB | PhosphoSitePlus |
| Dephosphorylation site |
| RHBT2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000251822 | V347M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000251822 | E456K | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| RHBT2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RHBT2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG2_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBG10_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBG12_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | RHBT2_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04120 | Ubiquitin mediated proteolysis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |