Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLCB3_HUMAN
Description:phospholipase C, beta 3 (phosphatidylinositol-specific) [Source:HGNC Symbol;Acc:9056]
Location:chr11 q13.1
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y428AKMAEyCRSIFPI-PLC-XPhosphoSitePlus
T1122KEAELtEINRRHPRD; RegPhos
S1105RKRHNsISEAKphosphoELM
T925PPGPTtSPASTHPRD; phosphoELM
S26TLRRGsKFIKWPKG1RegPhos
S26TLRRGsKFIKWPRKG2HPRD
Y847TEASDyIPDDHPhosphoSitePlus
S1105RKRHNsISEAKPKA_groupphosphoELM; RegPhos
S26TLRRGsKFIKWPRKG1HPRD
S814RILPVsAIRSGPhosphoSitePlus
S537LEPQKsLGDEGCaMK2gRegPhos
S537LEPQKsLGDEGCaMK2bRegPhos
Y548LNRGPyVLGPAPhosphoSitePlus
S929TTSPAsTSLSSHPRD
S1107RHNSIsEAKMRPLC-beta_CPhosphoSitePlus
S537LEPQKsLGDEGCaM-KII_alphaphosphoELM
Y746RKVGIyVEVDMC2PhosphoSitePlus
Y279LLIEKyEPNQQefhand_likePhosphoSitePlus
T1122KEAELtEINRRPLC-beta_CPhosphoSitePlus
S1105RKRHNsISEAKPKG2/cGK-IIphosphoELM
Y855DDHQDyAEALIPhosphoSitePlus
T924RPPGPtTSPASPhosphoSitePlus
S537LEPQKsLGDEGCaMK2aRegPhos
Y1031DEAKRyQEFQNS-methyl_trans; PLC-beta_PhosphoSitePlus
S931SPASTsLSSPGPhosphoSitePlus; HPRD; phosphoELM
S474KRHRPsAGGPDPhosphoSitePlus
S1105RKRHNsISEAKPLC-beta_CPhosphoSitePlus
S537LEPQKsLGDEGCAMK2GHPRD
S537LEPQKsLGDEGCAMK2BHPRD
S933ASTSLsSPGQRHPRD; phosphoELM
S1105RKRHNsISEAKPRKG2HPRD
S1105RKRHNsISEAKPRKG1HPRD
T1130NRRHItESVNSPLC-beta_CPhosphoSitePlus
S1105RKRHNsISEAKPKG1RegPhos
S1105RKRHNsISEAKPKG2RegPhos
S926PGPTTsPASTSHPRD; phosphoELM
S537LEPQKsLGDEGCaMK2_groupRegPhos
S934STSLSsPGQRDPhosphoSitePlus; HPRD; phosphoELM
S537LEPQKsLGDEGCaM-KII_groupphosphoELM
S26TLRRGsKFIKWPKG2RegPhos
S26TLRRGsKFIKWPKG2/cGK-IIphosphoELM
S537LEPQKsLGDEGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1105RKRHNsISEAKPKCa(PKC alphaRegPhos

Dephosphorylation site
PLCB3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000279230G1024ECOSMICPancreatic Cancer
ENSP00000279230R707QTCGAOvarian Cancer21720365, 18772890
ENSP00000443631R707QCOSMICOvarian Cancer21720365
ENSP00000279230R707QCOSMICOvarian Cancer21720365
ENSP00000443631R707QTCGAOvarian Cancer21720365, 18772890
ENSP00000443631G1024ECOSMICPancreatic Cancer

Differential expressed protein
PLCB3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLCB3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG13_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBG5_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GNA11_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBB3_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBB2_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBG10_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBB5_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBG12_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBG11_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBG3_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GNAQ_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBG2_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GNA15_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBG8_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBB1_HUMANPLCB3_HUMANGprotein -> effectorgpDB
GBG1_HUMANPLCB3_HUMANGprotein -> effectorgpDB
KCC2B_HUMANPLCB3_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPLCB3_HUMANkinase -> substrateRegPhos
KGP2_HUMANPLCB3_HUMANkinase -> substrateHPRD
KPCA_HUMANPLCB3_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANPLCB3_HUMANkinase -> substrateRobert H Newman (2013)
KGP1_HUMANPLCB3_HUMANkinase -> substrateHPRD
KCC2G_HUMANPLCB3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05143African trypanosomiasis
hsa04540Gap junction
hsa05016Huntington's disease
hsa04972Pancreatic secretion
hsa00562Inositol phosphate metabolism
hsa05146Amoebiasis
hsa04270Vascular smooth muscle contraction
hsa04723Retrograde endocannabinoid signaling
hsa04970Salivary secretion
hsa04020Calcium signaling pathway
hsa04720Long-term potentiation
hsa04726Serotonergic synapse
hsa04062Chemokine signaling pathway
hsa01100Metabolic pathways
hsa04728Dopaminergic synapse
hsa04912GnRH signaling pathway
hsa05010Alzheimer's disease
hsa04730Long-term depression
hsa04070Phosphatidylinositol signaling system
hsa04725Cholinergic synapse
hsa04916Melanogenesis
hsa04961Endocrine and other factor-regulated calcium reabs
hsa04971Gastric acid secretion
hsa05142Chagas disease (American trypanosomiasis)
hsa04724Glutamatergic synapse
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0006629lipid metabolic processIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0008081phosphoric diester hydrolase activityIEAmolecular_function
GO:0016042lipid catabolic processIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005516calmodulin bindingIPImolecular_function
GO:0043234protein complexIDAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0004629phospholipase C activityTASmolecular_function
GO:0005509calcium ion bindingIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004435phosphatidylinositol phospholipase C activityIEAmolecular_function
GO:0003073regulation of systemic arterial blood pressureIDAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23