| UniProt/SwissProt ID: | IRK15_HUMAN |
| Description: | potassium inwardly-rectifying channel, subfamily J, member 15 [Source:HGNC Symbol;Acc:6261] |
| Location: | chr21 q22.13 |
| Node attribute: | effector |
| Phosphorylation site |
| IRK15_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| IRK15_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000331698 | A71T | Sjoblom2006, HPI | Breast Cancer | 16959974 | ENSP00000381904 | K319* | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000381904 | V29I | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000381904 | Y355F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000381911 | A71T | Sjoblom2006, HPI | Breast Cancer | 16959974 | ENSP00000381904 | Y355F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000381907 | Y355F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000381904 | M76I | COSMIC | Melanoma | 21499247 | ENSP00000381904 | A71T | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000381911 | K319* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000381907 | K319* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000381907 | A71T | Sjoblom2006, HPI, BIOMART | Breast Cancer | 16959974, 21930507, 21930502 | ENSP00000381905 | A71T | Sjoblom2006, HPI | Breast Cancer | 16959974 | ENSP00000331698 | K319* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000381911 | Y355F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000381905 | Y355F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000381905 | K319* | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000331698 | Y355F | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| IRK15_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IRK15_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG13_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBG10_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBG12_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | IRK15_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04971 | Gastric acid secretion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006813 | potassium ion transport | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005267 | potassium channel activity | IEA | molecular_function |
| GO:0006813 | potassium ion transport | TAS | biological_process |
| GO:0005242 | inward rectifier potassium channel activity | IEA | molecular_function |
| GO:0071805 | potassium ion transmembrane transport | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |