Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARBK2_HUMAN
Description:adrenergic, beta, receptor kinase 2 [Source:HGNC Symbol;Acc:290]
Location:chr22 q12.1
Node attribute:effector; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T524QEVTEtVYEAVPhosphoSitePlus
S423SPELKsLLEGLPkinase_AGCPhosphoSitePlus
T353HASVGtHGYMAPkinase_AGCPhosphoSitePlus
S514FPLVIsERWQQPhosphoSitePlus
Y109RSRQIyDAYIMRGSPhosphoSitePlus
Y112QIYDAyIMKELRGSPhosphoSitePlus
Y206GFGEVyGCRKAPkinase_AGCPhosphoSitePlus
Y564CIMHGyMLKLGPHPhosphoSitePlus
S350KKPHAsVGTHGPkinase_AGCPhosphoSitePlus
Y526VTETVyEAVNAPhosphoSitePlus
Y356VGTHGyMAPEVPkinase_AGCPhosphoSitePlus
T672KPRSGtVELPKPhosphoSitePlus
S670LNKPRsGTVELPhosphoSitePlus
T612LSVEEtQIKDKPHPhosphoSitePlus

Dephosphorylation site
ARBK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000317578S244FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000317578R436WTCGAOvarian Cancer21720365, 18772890
ENSP00000317578R659PTCGAOvarian Cancer21720365, 18772890
ENSP00000317578G337DBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000317578R104KGreenman2007, HPILung Cancer16140923, 17344846, 18428421

Differential expressed protein
ARBK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ARBK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBB2_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBG12_HUMANARBK2_HUMANGprotein -> effectorgpDB
GNAQ_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBB3_HUMANARBK2_HUMANGprotein -> effectorgpDB
GNA11_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBG13_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBG11_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBG5_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBB1_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBG3_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBG1_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBG2_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBB5_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBG8_HUMANARBK2_HUMANGprotein -> effectorgpDB
GBG10_HUMANARBK2_HUMANGprotein -> effectorgpDB
ARBK2_HUMANCCR5_HUMANkinase -> substrateRegPhos
ARBK2_HUMANBKRB2_HUMANkinase -> substrateRegPhos
ARBK2_HUMANOPRM_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05032Morphine addiction
hsa04724Glutamatergic synapse
hsa04062Chemokine signaling pathway
hsa04740Olfactory transduction
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityTASmolecular_function
GO:0004703G-protein coupled receptor kinase activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0031623receptor internalizationIDAbiological_process
GO:0047696beta-adrenergic receptor kinase activityIEAmolecular_function
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005543phospholipid bindingIEAmolecular_function


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