Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRK8_HUMAN
Description:potassium inwardly-rectifying channel, subfamily J, member 8 [Source:HGNC Symbol;Acc:6269]
Location:chr12 p12.1
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T62LQDIFtTLVDLIRKPhosphoSitePlus
T283YDISAtDLANQIRKPhosphoSitePlus
S397MRRNNsIRRNNPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y278KRSPLyDISATIRKPhosphoSitePlus
S275VIDKRsPLYDIIRKPhosphoSitePlus
S194ETLIFsRHAVIIRKPhosphoSitePlus
S281PLYDIsATDLAIRKPhosphoSitePlus

Dephosphorylation site
IRK8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000240662E111DCOSMICHead and Neck Cancer21798893
ENSP00000240662L132PCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000240662Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.6715169874

Hyperphosphorylation site
IRK8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG5_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBG12_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBB5_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBG10_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBG11_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBG1_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBB3_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBG2_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBG13_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBG8_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBB1_HUMANIRK8_HUMANGprotein -> effectorgpDB
GBG3_HUMANIRK8_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
IRK8_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006813potassium ion transportTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007507heart developmentIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005242inward rectifier potassium channel activityTASmolecular_function
GO:0010107potassium ion importIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0015272ATP-activated inward rectifier potassium channel aIEAmolecular_function
GO:0030016myofibrilIEAcellular_component
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0008076voltage-gated potassium channel complexTAScellular_component
GO:0009268response to pHIEAbiological_process
GO:0043330response to exogenous dsRNAIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0042383sarcolemmaIEAcellular_component
GO:0008282ATP-sensitive potassium channel complexIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0042311vasodilationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006813potassium ion transportIEAbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process


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