| UniProt/SwissProt ID: | DNM1L_HUMAN |
| Description: | dynamin 1-like [Source:HGNC Symbol;Acc:2973] |
| Location: | chr12 p11.21 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S607 | LAEEKsKPIPI | PhosphoSitePlus; HPRD; phosphoELM | |
| T193 | NTDMAtSEALK | Dynamin_N | PhosphoSitePlus |
| S579 | PIMPAsPQKGH | HPRD | |
| S616 | PIMPAsPQKGH | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S529 | LPSAVsRDKSS | PhosphoSitePlus; HPRD | |
| S179 | ISNPNsIILAV | Dynamin_N | PhosphoSitePlus |
| T78 | EDKRKtTGEEN | Dynamin_N | PhosphoSitePlus |
| S684 | KDTLQsELVGQ | HPRD | |
| S658 | KDTLQsELVGQ | HPRD | |
| S570 | LAEEKsKPIPI | HPRD | |
| S581 | LAEEKsKPIPI | HPRD | |
| T400 | AIRNAtGPRPA | Dynamin_M | PhosphoSitePlus |
| S637 | VARKLsAREQR | PKA_group | phosphoELM |
| S590 | PIMPAsPQKGH | HPRD | |
| S647 | KDTLQsELVGQ | HPRD | |
| S412 | FVPEVsFELLV | Dynamin_M | PhosphoSitePlus |
| T193 | NTDMAtSEALK | HPRD | |
| T79 | DKRKTtGEENG | Dynamin_N | PhosphoSitePlus |
| S693 | GQLYKsSLLDD | PhosphoSitePlus | |
| S548 | ASQEPsPAASA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S194 | TDMATsEALKI | HPRD | |
| S637 | VARKLsAREQR | PhosphoSitePlus | |
| T586 | VQEPTtGNWRG | PhosphoSitePlus | |
| Dephosphorylation site |
| DNM1L_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000266481 | M439I | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| DNM1L_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DNM1L_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG10_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBG12_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | DNM1L_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa04961 | Endocrine and other factor-regulated calcium reabs |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa04721 | Synaptic vesicle cycle |
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006921 | cellular component disassembly involved in executi | TAS | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0090149 | membrane fission involved in mitochondrial fission | IDA | biological_process |
| GO:0005777 | peroxisome | IDA | cellular_component |
| GO:0043653 | mitochondrial fragmentation involved in apoptotic | IMP | biological_process |
| GO:1900063 | regulation of peroxisome organization | IMP | biological_process |
| GO:0051289 | protein homotetramerization | IDA | biological_process |
| GO:0005741 | mitochondrial outer membrane | IEA | cellular_component |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0003374 | dynamin polymerization involved in mitochondrial f | IDA | biological_process |
| GO:0031625 | ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0012505 | endomembrane system | IEA | cellular_component |
| GO:0090200 | positive regulation of release of cytochrome c fro | IMP | biological_process |
| GO:0050714 | positive regulation of protein secretion | IDA | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0070584 | mitochondrion morphogenesis | IMP | biological_process |
| GO:2001244 | positive regulation of intrinsic apoptotic signali | IMP | biological_process |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0043234 | protein complex | IDA | cellular_component |
| GO:0090141 | positive regulation of mitochondrial fission | TAS | biological_process |
| GO:0016559 | peroxisome fission | IDA | biological_process |
| GO:0005874 | microtubule | IDA | cellular_component |
| GO:0010821 | regulation of mitochondrion organization | IMP | biological_process |
| GO:0000266 | mitochondrial fission | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005741 | mitochondrial outer membrane | IDA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |