Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PK3CB_HUMAN
Description:phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [Source:HGNC Symbol;Acc:8976]
Location:chr3 q22.3
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S724LKTLNsLIKLNPhosphoSitePlus
Y436AGKVHyPVAWVPI3K_C2PhosphoSitePlus
S1070RKDYHPRD
Y246VSPYDyVLQVSPI3K_rbdPhosphoSitePlus
T961VPFILtYDFIHPI3_PI4_kinasePhosphoSitePlus
S1070RKDYRs_____PhosphoSitePlus
Y962PFILTyDFIHVPI3_PI4_kinasePhosphoSitePlus
S115KLVTRsCDPGEPI3K_p85BPhosphoSitePlus
Y505KQPYYyPPFDKPhosphoSitePlus
Y503NKKQPyYYPPFPhosphoSitePlus
T113VLKLVtRSCDPPI3K_p85BPhosphoSitePlus
Y504KKQPYyYPPFDPhosphoSitePlus
S1070RKDYPIK3CBphosphoELM
T427PSKYQtIRKAGPI3K_C2PhosphoSitePlus
Y425INPSKyQTIRKPI3K_C2PhosphoSitePlus
T721LNKLKtLNSLIPhosphoSitePlus
Y772ILSELyVEKCKPhosphoSitePlus; phosphoELM
S423KTINPsKYQTIPI3K_C2PhosphoSitePlus
T417KTKKStKTINPPI3K_C2PhosphoSitePlus
S416VKTKKsTKTINPI3K_C2PhosphoSitePlus
S947LGNFKsKFGIKPI3_PI4_kinasePhosphoSitePlus
S520AAEIAsSDSANPhosphoSitePlus
Y244DEVSPyDYVLQPI3K_rbdPhosphoSitePlus

Dephosphorylation site
PK3CB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000289153L313FBIOMARTBreast Cancer21930507, 21930502
ENSP00000289153Y638*COSMICMelanoma
ENSP00000418143I512MCOSMICOvarian Cancer21720365
ENSP00000418143R847GBIOMARTBreast Cancer21930507, 21930502
ENSP00000289153I512MCOSMICOvarian Cancer21720365
ENSP00000418143E633KCOSMICBreast Cancer20668451
ENSP00000289153R847GBIOMARTBreast Cancer21930507, 21930502
ENSP00000418143Y638*COSMICMelanoma
ENSP00000289153E633KCOSMICBreast Cancer20668451
ENSP00000418143L313FBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
PK3CB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PK3CB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG8_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBG2_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBB1_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBB5_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBG13_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBG5_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBB2_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBG3_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBG12_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBB3_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GNAQ_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBG1_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBG10_HUMANPK3CB_HUMANGprotein -> effectorgpDB
GBG11_HUMANPK3CB_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa05200Pathways in cancer
hsa04662B cell receptor signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa05160Hepatitis C
hsa04150mTOR signaling pathway
hsa04725Cholinergic synapse
hsa05221Acute myeloid leukemia
hsa04660T cell receptor signaling pathway
hsa04210Apoptosis
hsa04070Phosphatidylinositol signaling system
hsa04930Type II diabetes mellitus
hsa05223Non-small cell lung cancer
hsa05213Endometrial cancer
hsa04810Regulation of actin cytoskeleton
hsa05166HTLV-I infection
hsa05142Chagas disease (American trypanosomiasis)
hsa00562Inositol phosphate metabolism
hsa05203Viral carcinogenesis
hsa04664Fc epsilon RI signaling pathway
hsa04380Osteoclast differentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa05145Toxoplasmosis
hsa04670Leukocyte transendothelial migration
hsa04914Progesterone-mediated oocyte maturation
hsa05100Bacterial invasion of epithelial cells
hsa05164Influenza A
hsa05211Renal cell carcinoma
hsa04666Fc gamma R-mediated phagocytosis
hsa05212Pancreatic cancer
hsa04370VEGF signaling pathway
hsa04062Chemokine signaling pathway
hsa04012ErbB signaling pathway
hsa04973Carbohydrate digestion and absorption
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa05146Amoebiasis
hsa05210Colorectal cancer
hsa05218Melanoma
hsa04510Focal adhesion
hsa05169Epstein-Barr virus infection
hsa05214Glioma
hsa04620Toll-like receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05215Prostate cancer
hsa05162Measles
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016477cell migrationTASbiological_process
GO:0010508positive regulation of autophagyTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048015phosphatidylinositol-mediated signalingIEAbiological_process
GO:0006935chemotaxisTASbiological_process
GO:0001952regulation of cell-matrix adhesionIEAbiological_process
GO:0006914autophagyIEAbiological_process
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase actIEAmolecular_function
GO:0006897endocytosisIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0030168platelet activationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0036092phosphatidylinositol-3-phosphate biosynthetic procIEAbiological_process
GO:0043560insulin receptor substrate bindingIEAmolecular_function
GO:0005488bindingIEAmolecular_function
GO:2000369regulation of clathrin-mediated endocytosisTASbiological_process
GO:0070527platelet aggregationTASbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0007156homophilic cell adhesionIEAbiological_process
GO:0035004phosphatidylinositol 3-kinase activityTASmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeTASbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0007165signal transductionNASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:00163031-phosphatidylinositol-3-kinase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0040016embryonic cleavageIEAbiological_process
GO:0005515protein bindingIPImolecular_function


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