Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RHOB_HUMAN
Description:ras homolog family member B [Source:HGNC Symbol;Acc:668]
Location:chr2 p24.1
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S185QKRYGsQNGCIPhosphoSitePlus
Y66AGQEDyDRLRPRasPhosphoSitePlus
T129DEHVRtELARMRasPhosphoSitePlus
Y34EFPEVyVPTVFRasPhosphoSitePlus

Dephosphorylation site
RHOB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000272233E125KBIOMARTBreast Cancer21930507, 21930502
ENSP00000272233D13YDing2008, COSMICLung Cancer18948947
ENSP00000272233V127GTCGAOvarian Cancer21720365, 18772890
ENSP00000272233V127GCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000272233Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
RHOB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG3_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBG10_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBG11_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBG12_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBG5_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBG1_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBG2_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBB1_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBB3_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBB5_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBG8_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBG13_HUMANRHOB_HUMANGprotein -> effectorgpDB
GBB2_HUMANRHOB_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
RHOB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006184GTP catabolic processTASbiological_process
GO:0019003GDP bindingIEAmolecular_function
GO:0005634nucleusISScellular_component
GO:0007165signal transductionIEAbiological_process
GO:0071479cellular response to ionizing radiationIDAbiological_process
GO:0045786negative regulation of cell cycleISSbiological_process
GO:0045786negative regulation of cell cycleIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005525GTP bindingTASmolecular_function
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0008333endosome to lysosome transportIDAbiological_process
GO:0032154cleavage furrowIDAcellular_component
GO:0006927transformed cell apoptotic processISSbiological_process
GO:0006927transformed cell apoptotic processIEAbiological_process
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0070301cellular response to hydrogen peroxideIDAbiological_process
GO:0033205cell cycle cytokinesisIMPbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0015031protein transportIEAbiological_process
GO:0007155cell adhesionISSbiological_process
GO:0005829cytosolIEAcellular_component
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0031902late endosome membraneIEAcellular_component
GO:0010008endosome membraneIDAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0007266Rho protein signal transductionTASbiological_process
GO:0045766positive regulation of angiogenesisISSbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0005829cytosolTAScellular_component


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