Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	RHOB_HUMAN
Description:	ras homolog family member B [Source:HGNC Symbol;Acc:668]
Location:	chr2 p24.1
Node attribute:	effector

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S185	QKRYGsQNGCI		PhosphoSitePlus
Y66	AGQEDyDRLRP	Ras	PhosphoSitePlus
T129	DEHVRtELARM	Ras	PhosphoSitePlus
Y34	EFPEVyVPTVF	Ras	PhosphoSitePlus

Dephosphorylation site

RHOB_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000272233	E125K	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000272233	D13Y	Ding2008, COSMIC	Lung Cancer	18948947
ENSP00000272233	V127G	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000272233	V127G	COSMIC	Ovarian Cancer	21720365

Differential expressed protein

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000272233	Testicular Cancer	Normal vs. Cancer	cell line	Up		18489135

Hyperphosphorylation site

RHOB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
GBG3_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBG10_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBG11_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBG12_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBG5_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBG1_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBG2_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBB1_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBB3_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBB5_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBG8_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBG13_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB
GBB2_HUMAN	RHOB_HUMAN	Gprotein -> effector	gpDB

Function Annotation

KEGG Pathway

RHOB_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0006184	GTP catabolic process	TAS	biological_process
GO:0019003	GDP binding	IEA	molecular_function
GO:0005634	nucleus	ISS	cellular_component
GO:0007165	signal transduction	IEA	biological_process
GO:0071479	cellular response to ionizing radiation	IDA	biological_process
GO:0045786	negative regulation of cell cycle	ISS	biological_process
GO:0045786	negative regulation of cell cycle	IEA	biological_process
GO:0030168	platelet activation	TAS	biological_process
GO:0005525	GTP binding	TAS	molecular_function
GO:0007264	small GTPase mediated signal transduction	TAS	biological_process
GO:0001525	angiogenesis	IEA	biological_process
GO:0007411	axon guidance	TAS	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0008333	endosome to lysosome transport	IDA	biological_process
GO:0032154	cleavage furrow	IDA	cellular_component
GO:0006927	transformed cell apoptotic process	ISS	biological_process
GO:0006927	transformed cell apoptotic process	IEA	biological_process
GO:0043065	positive regulation of apoptotic process	IMP	biological_process
GO:0070301	cellular response to hydrogen peroxide	IDA	biological_process
GO:0033205	cell cycle cytokinesis	IMP	biological_process
GO:0051056	regulation of small GTPase mediated signal transdu	TAS	biological_process
GO:0005622	intracellular	IEA	cellular_component
GO:0005515	protein binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0006915	apoptotic process	TAS	biological_process
GO:0007596	blood coagulation	TAS	biological_process
GO:0015031	protein transport	IEA	biological_process
GO:0007155	cell adhesion	ISS	biological_process
GO:0005829	cytosol	IEA	cellular_component
GO:0045766	positive regulation of angiogenesis	IEA	biological_process
GO:0031902	late endosome membrane	IEA	cellular_component
GO:0010008	endosome membrane	IDA	cellular_component
GO:0007155	cell adhesion	IEA	biological_process
GO:0007266	Rho protein signal transduction	TAS	biological_process
GO:0045766	positive regulation of angiogenesis	ISS	biological_process
GO:0003924	GTPase activity	TAS	molecular_function
GO:0005829	cytosol	TAS	cellular_component

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network