Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLCB2_HUMAN
Description:phospholipase C, beta 2 [Source:HGNC Symbol;Acc:9055]
Location:chr15 q15.1
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y718DPKRRyRTKLSC2PhosphoSitePlus
T332HNTYLtAGQFSPI-PLC-XPhosphoSitePlus
S337TAGQFsGLSSAPI-PLC-XPhosphoSitePlus
Y604QMSRIyPKGTRPI-PLC-YPhosphoSitePlus
Y571QKNRSyVISSFPI-PLC-YPhosphoSitePlus
S953GPGKGsRKKRSPhosphoSitePlus
S575SYVISsFTELKPI-PLC-YPhosphoSitePlus
S474GPTSSsKDTGGPhosphoSitePlus
S1036ALKETsENDTKPhosphoSitePlus
S450GVPLPsPEDLRPI-PLC-XPhosphoSitePlus
S728SPSTNsINPVWHPRD
S570AQKNRsYVISSPI-PLC-YPhosphoSitePlus
S63FLDITsIRDTRHPRD
T1040TSENDtKEMKKPhosphoSitePlus
S672QFNPFsVDRIDPhosphoSitePlus
S601NKRQMsRIYPKPI-PLC-YPhosphoSitePlus
S597NKRQMsRIYPKphosphoELM
S574RSYVIsSFTELPI-PLC-YPhosphoSitePlus
T62EFLDItSIRDTHPRD
T1035KALKEtSENDTPhosphoSitePlus
Y600QMSRIyPKGTRphosphoELM

Dephosphorylation site
PLCB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260402S394RBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
PLCB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLCB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBB3_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBB2_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBG12_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GNAQ_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GNA15_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBG10_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBG1_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBG13_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GNA11_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBG8_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBB1_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBG2_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBG3_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBB5_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBG5_HUMANPLCB2_HUMANGprotein -> effectorgpDB
GBG11_HUMANPLCB2_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04724Glutamatergic synapse
hsa04973Carbohydrate digestion and absorption
hsa04970Salivary secretion
hsa04270Vascular smooth muscle contraction
hsa04723Retrograde endocannabinoid signaling
hsa04070Phosphatidylinositol signaling system
hsa04020Calcium signaling pathway
hsa04961Endocrine and other factor-regulated calcium reabs
hsa05016Huntington's disease
hsa05143African trypanosomiasis
hsa04912GnRH signaling pathway
hsa04730Long-term depression
hsa04725Cholinergic synapse
hsa05142Chagas disease (American trypanosomiasis)
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa01100Metabolic pathways
hsa04742Taste transduction
hsa04971Gastric acid secretion
hsa04720Long-term potentiation
hsa05010Alzheimer's disease
hsa04726Serotonergic synapse
hsa05146Amoebiasis
hsa04540Gap junction
hsa04062Chemokine signaling pathway
hsa04972Pancreatic secretion
hsa04728Dopaminergic synapse
hsa00562Inositol phosphate metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004435phosphatidylinositol phospholipase C activityIEAmolecular_function
GO:0016042lipid catabolic processIEAbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0008081phosphoric diester hydrolase activityIEAmolecular_function
GO:0004629phospholipase C activityTASmolecular_function
GO:0006644phospholipid metabolic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0050913sensory perception of bitter tasteIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0004871signal transducer activityIEAmolecular_function


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