| UniProt/SwissProt ID: | SHC3_HUMAN |
| Description: | SHC (Src homology 2 domain containing) transforming protein 3 [Source:HGNC Symbol;Acc:18181] |
| Location: | chr9 q22.1 |
| Node attribute: | effector; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S337 | EEGDGsDHPYY | PhosphoSitePlus | |
| Y341 | GSDHPyYNSIP | PhosphoSitePlus | |
| Y46 | PAAAPyLVSGE | PhosphoSitePlus | |
| Y308 | LRFKQyLQCPT | PID | PhosphoSitePlus |
| S224 | QFAGMsISLTI | PID | PhosphoSitePlus |
| S210 | PSKMLsSILGK | PID | PhosphoSitePlus |
| Y406 | GSSDIySTPEG | PhosphoSitePlus | |
| Y424 | GEAPTyVNTQQ | PhosphoSitePlus | |
| S407 | SSDIYsTPEGK | PhosphoSitePlus | |
| Y379 | GKEQTyYQGRH | PhosphoSitePlus | |
| Y342 | SDHPYyNSIPS | PhosphoSitePlus | |
| Dephosphorylation site |
| SHC3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364995 | S407T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000364995 | P422T | COSMIC | Lung Cancer | 20016488 |
| Differential expressed protein |
| SHC3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SHC3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG10_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBG12_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | SHC3_HUMAN | Gprotein -> effector | gpDB |
| FAK1_HUMAN | SHC3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RET_HUMAN | SHC3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04910 | Insulin signaling pathway |
| hsa05034 | Alcoholism |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa04510 | Focal adhesion |
| hsa04062 | Chemokine signaling pathway |
| hsa04012 | ErbB signaling pathway |
| hsa05220 | Chronic myeloid leukemia |
| hsa05214 | Glioma |
| hsa04722 | Neurotrophin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007611 | learning or memory | IEA | biological_process |
| GO:0035249 | synaptic transmission, glutamatergic | IEA | biological_process |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007417 | central nervous system development | TAS | biological_process |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | TAS | biological_process |
| GO:0004871 | signal transducer activity | TAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0035556 | intracellular signal transduction | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005575 | cellular_component | ND | cellular_component |