Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RGRF1_HUMAN
Description:Ras protein-specific guanine nucleotide-releasing factor 1 [Source:HGNC Symbol;Acc:9875]
Location:chr15 q25.1
Node attribute:PPI(target); substrate; effector; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S752KTSSPsRRRKLRasGEF_NPhosphoSitePlus
S738ATRKFsSPPPLRasGEF_NPhosphoSitePlus
S929KYRRMsLASAGphosphoELM; RegPhos
S789YTSMYsAMSPFPhosphoSitePlus
T1025TLEEItQMAEGPhosphoSitePlus
S1097SNLIAsEIIRNRasGEFPhosphoSitePlus
S750ITKTSsPSRRRRasGEF_NPhosphoSitePlus
Y784CNSNGyTSMYSRasGEF_NPhosphoSitePlus
S709ARWLRsLELLFRasGEF_NPhosphoSitePlus
S929KYRRMsLASAGPKACaRegPhos
S929KYRRMsLASAGRasGEF_NPhosphoSitePlus
S1254YLLDQsFVMDEPhosphoSitePlus
S739TRKFSsPPPLSRegPhos
S1092HFNDIsNLIASRasGEFPhosphoSitePlus
S143KYRRMsLASAGPRKACAHPRD
Y788GYTSMySAMSPPhosphoSitePlus

Dephosphorylation site
RGRF1_HUMAN do not have dephosphorylation site.

Mutation site
RGRF1_HUMAN do not have mutation site.

Differential expressed protein
RGRF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RGRF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG13_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBG1_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBB2_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBG11_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBG3_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBB3_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBG10_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBG8_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBG2_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBB5_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBG12_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBB1_HUMANRGRF1_HUMANGprotein -> effectorgpDB
GBG5_HUMANRGRF1_HUMANGprotein -> effectorgpDB
KPCA_HUMANRGRF1_HUMANkinase -> substrateHPRD
FAK1_HUMANRGRF1_HUMANkinase -> substrateKEGG
ZAGL2_HUMANRGRF1_HUMANkinase -> substrateRegPhos
IKKA_HUMANRGRF1_HUMANotherKEGG
RGRF1_HUMANRRAS2_HUMANotherKEGG
RGRF1_HUMANRHOA_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005886plasma membraneNAScellular_component
GO:0005622intracellularIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0048167regulation of synaptic plasticityISSbiological_process
GO:0043005neuron projectionNAScellular_component
GO:0005085guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0031175neuron projection developmentISSbiological_process
GO:0030426growth coneISScellular_component
GO:0007616long-term memoryNASbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0032863activation of Rac GTPase activityISSbiological_process
GO:0005829cytosolISScellular_component
GO:0032320positive regulation of Ras GTPase activityISSbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0046579positive regulation of Ras protein signal transducISSbiological_process
GO:0005088Ras guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0046578regulation of Ras protein signal transductionISSbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0035020regulation of Rac protein signal transductionISSbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process


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