| UniProt/SwissProt ID: | NLK_HUMAN |
| Description: | nemo-like kinase [Source:HGNC Symbol;Acc:29858] |
| Location: | chr17 q11.2 |
| Node attribute: | substrate; kinase; phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T367 | LEAMRtACEGA | Pkinase | PhosphoSitePlus |
| S274 | NLLVNsNCVLK | Pkinase | PhosphoSitePlus |
| T298 | ESRHMtQEVVT | HPRD | |
| S522 | SEMPPsPLVWE | PhosphoSitePlus | |
| S385 | PHKQPsLPVLY | Pkinase | PhosphoSitePlus |
| T298 | ESRHMtQEVVT | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| NLK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000384625 | Y216C | COSMIC | Lung Cancer | 20668451 | ENSP00000384625 | A343T | HPI | Neoplasms by Histologic Type | 17344846 | ENSP00000384625 | P235T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384625 | R287T | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| NLK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NLK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M3K7_HUMAN | NLK_HUMAN | kinase -> substrate | KEGG |
| NLK_HUMAN | NFAC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NLK_HUMAN | NLK_HUMAN | kinase -> substrate | NetPath |
| NLK_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NLK_HUMAN | LEF1_HUMAN | kinase -> substrate | RegPhos; NetPath; Robert H Newman (2013) |
| NLK_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NLK_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NLK_HUMAN | TF7L2_HUMAN | kinase -> substrate | NetPath |
| BMPR2_HUMAN | NLK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NLK_HUMAN | SETB1_HUMAN | phosphatase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa04520 | Adherens junction |
| hsa04310 | Wnt signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0018107 | peptidyl-threonine phosphorylation | IEA | biological_process |
| GO:0004707 | MAP kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0000287 | magnesium ion binding | IEA | molecular_function |
| GO:0007243 | intracellular protein kinase cascade | IEA | biological_process |
| GO:0000165 | MAPK cascade | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0031625 | ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0042169 | SH2 domain binding | IEA | molecular_function |
| GO:0033136 | serine phosphorylation of STAT3 protein | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007243 | intracellular protein kinase cascade | ISS | biological_process |
| GO:0007179 | transforming growth factor beta receptor signaling | IMP | biological_process |
| GO:0046777 | protein autophosphorylation | IEA | biological_process |
| GO:0030178 | negative regulation of Wnt receptor signaling path | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006468 | protein phosphorylation | ISS | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |