Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NLK_HUMAN
Description:nemo-like kinase [Source:HGNC Symbol;Acc:29858]
Location:chr17 q11.2
Node attribute:substrate; kinase; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T367LEAMRtACEGAPkinasePhosphoSitePlus
S274NLLVNsNCVLKPkinasePhosphoSitePlus
T298ESRHMtQEVVTHPRD
S522SEMPPsPLVWEPhosphoSitePlus
S385PHKQPsLPVLYPkinasePhosphoSitePlus
T298ESRHMtQEVVTPkinasePhosphoSitePlus

Dephosphorylation site
NLK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384625Y216CCOSMICLung Cancer20668451
ENSP00000384625A343THPINeoplasms by Histologic Type17344846
ENSP00000384625P235TTCGAOvarian Cancer21720365, 18772890
ENSP00000384625R287TCOSMICHead and Neck Cancer21798893

Differential expressed protein
NLK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NLK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K7_HUMANNLK_HUMANkinase -> substrateKEGG
NLK_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
NLK_HUMANNLK_HUMANkinase -> substrateNetPath
NLK_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
NLK_HUMANLEF1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
NLK_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
NLK_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
NLK_HUMANTF7L2_HUMANkinase -> substrateNetPath
BMPR2_HUMANNLK_HUMANkinase -> substrateRobert H Newman (2013)
NLK_HUMANSETB1_HUMANphosphatase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04520Adherens junction
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0004707MAP kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0042169SH2 domain bindingIEAmolecular_function
GO:0033136serine phosphorylation of STAT3 proteinIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007243intracellular protein kinase cascadeISSbiological_process
GO:0007179transforming growth factor beta receptor signalingIMPbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process


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