Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ABL2_HUMAN
Description:v-abl Abelson murine leukemia viral oncogene homolog 2 [Source:HGNC Symbol;Acc:77]
Location:chr1 q25.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S31SAARPsGRRRDPhosphoSitePlus; HPRD
S900VPVLIsPTLKHHPRD
T784PRSNStSSMSSPhosphoSitePlus; HPRD; phosphoELM
T1050QVPLPtSSISPHPRD; phosphoELM
S311VWKKYsLTVAVPkinase_TyrPhosphoSitePlus
S566DATENsASSLAHPRD
S820TVSTSsQPEENPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y683QPHKKyELTGNPhosphoSitePlus
T313KKYSLtVAVKTHPRD
Y310GVWKKySLTVAPkinase_TyrPhosphoSitePlus
S203RESESsPGQLSHPRD; SysPTM
S597RDKSPsSLLEDHPRD
Y213SISLRyEGRVYSH2PhosphoSitePlus
S582GAQASsGSPALHPRD
S936VPVLIsPTLKHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S819RTVSTsSQPEEPhosphoSitePlus
S25RGIRGsSAARPHPRD
S617RGAQAsSGSPAHPRD
Y231ADGKVyVTAESHPRD; SysPTM
S866PLRTPsGDLAIPhosphoSitePlus
Y116LFVALyDFVASSH3_1PhosphoSitePlus; SysPTM
T404TGDTYtAHAGAHPRD
Y568SSVVPyLPRLPPhosphoSitePlus
Y139LRVLGyNQNGESH3_1PhosphoSitePlus
Y718VPPKCyGGSFAPhosphoSitePlus; HPRD; SysPTM
Y439MTGDTyTAHAGPkinase_TyrPhosphoSitePlus
S96EAIRWsSKENLPhosphoSitePlus; HPRD
S275TVYGVsPIHDKPhosphoSitePlus; HPRD; SysPTM
T779LQLERtVSTSSHPRD
S789TSSMSsGLPEQHPRD
S208SPGQLsISLRYSH2PhosphoSitePlus
T753ITGFFtPRLIKPhosphoSitePlus
S631KQRDKsPSSLLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T581PSKTRtLKKQVPhosphoSitePlus
T402LMTGDtYTAHAHPRD
Y174EKHSWyHGPVSSH2PhosphoSitePlus
T163PSNYItPVNSLPhosphoSitePlus
T440TGDTYtAHAGAHPRD; phosphoELM
Y299LGGGQyGEVYVPkinase_TyrPhosphoSitePlus
T748PRSNStSSMSSHPRD
Y515CPPKVyELMRAphosphoELM
S783FPRSNsTSSMSPhosphoSitePlus; HPRD; phosphoELM
Y218YEGRVyHYRINSH2PhosphoSitePlus
S164FLVREsESSPGHPRD
S172SPGQLsISLRYHPRD
S239TVYGVsPIHDKHPRD
S584QASSGsPALPRHPRD
Y272NKPTVyGVSPIPhosphoSitePlus; HPRD
T438LMTGDtYTAHAPkinase_TyrPhosphoSitePlus
S633RDKSPsSLLEDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T828ALPLRtPSGDLHPRD
S932EHQVTsSGDKDHPRD
S968EHQVTsSGDKDHPRD
T277KKYSLtVAVKTHPRD
T782ERTVStSSQPEHPRD
T1014QVPLPtSSISPHPRD
T599GAQDAtENSASHPRD
S753TSSMSsGLPEQHPRD
T818ERTVStSSQPEPhosphoSitePlus; HPRD
S915QPGWPsPAKAAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S159QGWVPsNYITPSH3_1PhosphoSitePlus
S581RGAQAsSGSPAHPRD
S577LPILPsKTRTLPhosphoSitePlus
S671PKRSSsFREMEPhosphoSitePlus; HPRD; SysPTM
Y261VTTLHyPAPKCPhosphoSitePlus; phosphoELM
S71DKTGGsSPEALPhosphoSitePlus; HPRD; phosphoELM
Y459PESLAyNTFSIPkinase_TyrPhosphoSitePlus
S595KQRDKsPSSLLHPRD
Y195ADGKVyVTAESHPRD
S602DATENsASSLAPhosphoSitePlus; HPRD; SysPTM
S620QASSGsPALPRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S26GIRGSsAARPSHPRD
Y310GVWKKySLTVAphosphoELM
Y236NKPTVyGVSPIHPRD
T68FEGDKtGGSSPPhosphoSitePlus; HPRD
S745KPFPRsNSTSSHPRD
S879QPGWPsPAKAAHPRD
T452FPIKWtAPESLPkinase_TyrPhosphoSitePlus
S784TVSTSsQPEENHPRD
S72KTGGSsPEALHPhosphoSitePlus
S781LERTVsTSSQPHPRD
S1054PTSSIsPAKMAHPRD; phosphoELM
Y80LFVALyDFVASHPRD
T313KKYSLtVAVKTPkinase_TyrPhosphoSitePlus
S747FPRSNsTSSMSHPRD
S619GGFFSsFMKKRHPRD
Y515CPPKVyELMRAPkinase_TyrPhosphoSitePlus
S121YDFVAsGDNTLSH3_1PhosphoSitePlus
T440TGDTYtAHAGAPkinase_TyrPhosphoSitePlus
Y231ADGKVyVTAESSH2PhosphoSitePlus; SysPTM
S788STSSMsSGLPEHPRD
T815LQLERtVSTSSPhosphoSitePlus; HPRD; phosphoELM
Y303QYGEVyVGVWKPkinase_TyrPhosphoSitePlus
T902VLISPtLKHTPHPRD
S1018PTSSIsPAKMAHPRD
S635PKRSSsFREMEHPRD
T563GAQDAtENSASHPRD
T938VLISPtLKHTPPhosphoSitePlus; HPRD
S655GGFFSsFMKKRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S208SPGQLsISLRYHPRD
T438LMTGDtYTAHAHPRD
Y439MTGDTyTAHAGphosphoELM
T864ALPLRtPSGDLPhosphoSitePlus; HPRD; SysPTM
S817LERTVsTSSQPPhosphoSitePlus; HPRD; phosphoELM
T435LSRLMtGDTYTPkinase_TyrPhosphoSitePlus
S200FLVREsESSPGHPRD; phosphoELM
Y682VPPKCyGGSFAHPRD
S194SLINGsFLVRESH2PhosphoSitePlus
S203RESESsPGQLSSH2PhosphoSitePlus; SysPTM
S97AIRWSsKENLLPhosphoSitePlus
S634DKSPSsLLEDAHPRD
S598DKSPSsLLEDAHPRD
Y116LFVALyDFVASHPRD; SysPTM
S618GAQASsGSPALHPRD
Y161WVPSNyITPVNPhosphoSitePlus
S60EAIRWsSKENLHPRD
S752STSSMsSGLPEHPRD
S167RESESsPGQLSHPRD
S781KPFPRsNSTSSHPRD

Dephosphorylation site
ABL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000375897R357QBIOMARTBreast Cancer21930507, 21930502
ENSP00000427562R378QBIOMARTBreast Cancer21930507, 21930502
ENSP00000426831R342QBIOMARTBreast Cancer21930507, 21930502
ENSP00000423578R363QBIOMARTBreast Cancer21930507, 21930502
ENSP00000427562K835TBIOMARTBreast Cancer21930507, 21930502
ENSP00000339209R363QBIOMARTBreast Cancer21930507, 21930502
ENSP00000339209K717TBIOMARTBreast Cancer21930507, 21930502
ENSP00000426831K696TBIOMARTBreast Cancer21930507, 21930502
ENSP00000423578K820TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ABL2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ABL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ABL2_HUMANSIVA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ABL2_HUMANGLYAT_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ABL2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
ABL2_HUMANGPX1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ABL2_HUMANCRK_HUMANkinase -> substrateHPRD; RegPhos
ABL2_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05416Viral myocarditis
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030100regulation of endocytosisTASbiological_process
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0007411axon guidanceTASbiological_process
GO:0051353positive regulation of oxidoreductase activityIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0015629actin cytoskeletonIEAcellular_component
GO:0007015actin filament organizationIEAbiological_process
GO:0015629actin cytoskeletonTAScellular_component
GO:0010506regulation of autophagyTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:2000249regulation of actin cytoskeleton reorganizationTASbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0051017actin filament bundle assemblyIEAbiological_process
GO:0071300cellular response to retinoic acidIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0010976positive regulation of neuron projection developmeIMPbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:2000145regulation of cell motilityTASbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0030145manganese ion bindingIDAmolecular_function
GO:0004715non-membrane spanning protein tyrosine kinase actiTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0051015actin filament bindingTASmolecular_function
GO:0030155regulation of cell adhesionTASbiological_process
GO:0006464cellular protein modification processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0003785actin monomer bindingTASmolecular_function