| UniProt/SwissProt ID: | NEK7_HUMAN |
| Description: | NIMA-related kinase 7 [Source:HGNC Symbol;Acc:13386] |
| Location: | chr1 q31.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S147 | FVQLCsALEHM | Pkinase | PhosphoSitePlus |
| T199 | HSLVGtPYYMS | Pkinase | PhosphoSitePlus |
| Y97 | PNVIKyYASFI | Pkinase | PhosphoSitePlus |
| Y201 | LVGTPyYMSPE | Pkinase | PhosphoSitePlus |
| S187 | LGRFFsSKTTA | Pkinase | PhosphoSitePlus |
| S5 | _MDEQsQGMQG | PhosphoSitePlus | |
| T199 | HSLVGtPYYMS | HPRD | |
| S195 | TTAAHsLVGTP | NEK9 | HPRD; phosphoELM; RegPhos |
| S188 | GRFFSsKTTAA | Pkinase | PhosphoSitePlus |
| S187 | LGRFFsSKTTA | HPRD | |
| T190 | FFSSKtTAAHS | HPRD | |
| T191 | FSSKTtAAHSL | Pkinase | PhosphoSitePlus |
| Y202 | VGTPYyMSPER | Pkinase | PhosphoSitePlus |
| S204 | TPYYMsPERIH | HPRD; phosphoELM; SysPTM | |
| Y289 | DVTYVyDVAKR | Pkinase | PhosphoSitePlus |
| S195 | TTAAHsLVGTP | Pkinase | PhosphoSitePlus |
| T286 | KRPDVtYVYDV | Pkinase | PhosphoSitePlus |
| T30 | DMGYNtLANFR | PhosphoSitePlus | |
| T190 | FFSSKtTAAHS | Pkinase | PhosphoSitePlus |
| S188 | GRFFSsKTTAA | HPRD | |
| Y244 | DKMNLySLCKK | Pkinase | PhosphoSitePlus |
| S204 | TPYYMsPERIH | Pkinase | PhosphoSitePlus; SysPTM |
| Y201 | LVGTPyYMSPE | HPRD; phosphoELM | |
| Y287 | RPDVTyVYDVA | Pkinase | PhosphoSitePlus |
| Y202 | VGTPYyMSPER | HPRD | |
| Dephosphorylation site |
| NEK7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356355 | G7* | Greenman2007 | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000356355 | I275M | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000356353 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.47 | 20052998 | ENSP00000356353 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.65 | 20052998 | ENSP00000356353 | Breast Cancer | Metastasis | cell line | Up | 1.7 | 20052998 |
| Hyperphosphorylation site |
| NEK7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK7_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK7_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK9_HUMAN | NEK7_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NEK7_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007346 | regulation of mitotic cell cycle | TAS | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0000922 | spindle pole | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005874 | microtubule | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005815 | microtubule organizing center | IEA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0051225 | spindle assembly | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0000910 | cytokinesis | TAS | biological_process |