Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MAST1_HUMAN
Description:microtubule associated serine/threonine kinase 1 [Source:HGNC Symbol;Acc:19034]
Location:chr19 p13.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S919SATALsVMIPAPhosphoSitePlus
S163RSRSLsPGRSPHPRD
T140KHFGStESITDDUF1908PhosphoSitePlus
T1431SGEAGtPLVPIPhosphoSitePlus
S1426GRRSSsGEAGTPhosphoSitePlus
S736AAAGSsKREPSPhosphoSitePlus
T728QHEPKtPVAAAPhosphoSitePlus
S283LLIIIsRPARLDUF1908PhosphoSitePlus
S142FGSTEsITDEDDUF1908PhosphoSitePlus
S1356SRPPVsSKEKEHPRD
S69SPRNFsPNTPADUF1908PhosphoSitePlus
Y323TDIPRyIIRQLDUF1908PhosphoSitePlus
Y182MMNHVyKERFPDUF1908PhosphoSitePlus
S283LLIIIsRPARLHPRD
S139SKHFGsTESITDUF1908PhosphoSitePlus
S64SSPLDsPRNFSDUF1908PhosphoSitePlus
S163RSRSLsPGRSPDUF1908PhosphoSitePlus
S782SASEAsFLEGEHPRD
S1258AEPPRsPLLKRPhosphoSitePlus
S1351LPEGAsRPPVSHPRD
Y491EYLHNyGIVHRPkinase_AGCPhosphoSitePlus
S789LEGEAsPPLGAHPRD
S161RPRSRsLSPGRHPRD
S152DGGRRsPAVRPDUF1908PhosphoSitePlus
S161RPRSRsLSPGRDUF1908PhosphoSitePlus
Y715RFSKVySSMEQPhosphoSitePlus
T45TSTSPtLPRPHPhosphoSitePlus
S1252RPRPKsAEPPRPhosphoSitePlus
Y487VLALEyLHNYGPkinase_AGCPhosphoSitePlus

Dephosphorylation site
MAST1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000251472H1240YGreenman2007, COSMIC, HPIOvarian Cancer17344846, 18428421
ENSP00000251472A269DCOSMICOvarian Cancer21720365
ENSP00000251472Q415HTCGAOvarian Cancer21720365, 18772890
ENSP00000251472D872GCOSMICOvarian Cancer21720365
ENSP00000251472D872GTCGAOvarian Cancer21720365, 18772890
ENSP00000251472S1306NDing2008, COSMICLung Cancer18948947
ENSP00000251472R820SDing2008, COSMICLung Cancer18948947
ENSP00000251472A269DTCGAOvarian Cancer21720365, 18772890
ENSP00000251472H119QBIOMARTBreast Cancer21930507, 21930502
ENSP00000251472Q415HCOSMICOvarian Cancer21720365
ENSP00000251472A269TGreenman2007Skin Cancer17344846, 18428421

Differential expressed protein
MAST1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MAST1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MAST1_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MAST1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
MAST1_HUMANGRK5_HUMANkinase -> substrateRobert H Newman (2013)
MAST1_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
MAST1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MAST1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000287magnesium ion bindingISSmolecular_function
GO:0006468protein phosphorylationISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0007010cytoskeleton organizationISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005524ATP bindingISSmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0007243intracellular protein kinase cascadeISSbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityISSmolecular_function


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