Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NEK6_HUMAN
Description:NIMA-related kinase 6 [Source:HGNC Symbol;Acc:7749]
Location:chr9 q33.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T202FSSETtAAHSLphosphoELM; RegPhos
T69QRHPNtLSFRCHPRD
S158FVQLCsAVEHMPkinasePhosphoSitePlus
Y212LVGTPyYMSPEPkinasePhosphoSitePlus
T201FFSSEtTAAHSPkinasePhosphoSitePlus
T35QRHPNtLSFRCPhosphoSitePlus; HPRD
S199GRFFSsETTAAPkinasePhosphoSitePlus
S37HPNTLsFRCSLPhosphoSitePlus
T210HSLVGtPYYMSPkinasePhosphoSitePlus
Y213VGTPYyMSPERPkinasePhosphoSitePlus
S206TTAAHsLVGTPPkinasePhosphoSitePlus
Y108PNIIKyLDSFIPkinasePhosphoSitePlus
S165VEHMHsRRVMHPkinasePhosphoSitePlus
S206TTAAHsLVGTPNEK9HPRD; phosphoELM; RegPhos
S215TPYYMsPERIHPkinasePhosphoSitePlus
T202FSSETtAAHSLPkinasePhosphoSitePlus
Y152RTVWKyFVQLCPkinasePhosphoSitePlus

Dephosphorylation site
NEK6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377749Y300CTCGAOvarian Cancer21720365, 18772890
ENSP00000362702Y300CTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
NEK6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NEK6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK6_HUMANSRA1_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANDCP1A_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANNEK6_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
STK24_HUMANNEK6_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANZN346_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANPSA7_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANPSA7L_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANSGK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
NEK6_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANPDK2_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANFABP4_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANKAT5_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANSMC3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANNEK6_HUMANkinase -> substrateRegPhos
NEK6_HUMANMFN1_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANNAA16_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANRAB14_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NEK6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000922spindle poleIEAcellular_component
GO:0030071regulation of mitotic metaphase/anaphase transitioIDAbiological_process
GO:0007059chromosome segregationIDAbiological_process
GO:0007165signal transductionIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0051225spindle assemblyTASbiological_process
GO:0031572G2/M transition DNA damage checkpointIMPbiological_process
GO:0000910cytokinesisTASbiological_process
GO:2000772regulation of cellular senescenceTASbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016607nuclear speckIEAcellular_component
GO:0005874microtubuleIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007346regulation of mitotic cell cycleTASbiological_process
GO:0005815microtubule organizing centerIEAcellular_component
GO:0004871signal transducer activityIMPmolecular_function
GO:0007067mitosisIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0019894kinesin bindingIPImolecular_function


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