| UniProt/SwissProt ID: | MATK_HUMAN |
| Description: | megakaryocyte-associated tyrosine kinase [Source:HGNC Symbol;Acc:6906] |
| Location: | chr19 p13.3 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S502 | ADGSTsPRSQ | HPRD | |
| S463 | STSPRsQ | HPRD | |
| S504 | STSPRsQEP__ | PhosphoSitePlus | |
| S460 | ADGSTsPRSQ | HPRD | |
| S505 | STSPRsQ | HPRD | |
| S85 | ACENKsWYRVK | SH3_1 | PhosphoSitePlus |
| T501 | DADGStSPRSQ | HPRD | |
| T500 | DADGStSPRSQ | PhosphoSitePlus; HPRD; phosphoELM | |
| S504 | STSPRsQ | HPRD; phosphoELM | |
| T459 | DADGStSPRSQ | HPRD | |
| T76 | KGDVVtILEAC | SH3_1 | PhosphoSitePlus |
| S501 | ADGSTsPRSQE | PhosphoSitePlus; SysPTM | |
| S501 | ADGSTsPRSQ | HPRD; phosphoELM; SysPTM | |
| Y87 | ENKSWyRVKHH | SH3_1 | PhosphoSitePlus |
| Dephosphorylation site |
| MATK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000308734 | R503Q | HPI | Colorectal Cancer | 17344846 | ENSP00000308734 | R503Q | Greenman2007 | Intestines Cancer | 17344846, 18428421 | ENSP00000308734 | A354T | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 | ENSP00000378485 | E417A | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 |
| Differential expressed protein |
| MATK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MATK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MATK_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MATK_HUMAN | LYN_HUMAN | kinase -> substrate | HPRD; RegPhos |
| MATK_HUMAN | MDFI_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MATK_HUMAN | FGR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04722 | Neurotrophin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0007498 | mesoderm development | TAS | biological_process |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | TAS | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |