| UniProt/SwissProt ID: | NRBP_HUMAN |
| Description: | nuclear receptor binding protein 1 [Source:HGNC Symbol;Acc:7993] |
| Location: | chr2 p23.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S12 | QTVLSsGSDPK | HPRD | |
| T431 | PPSVKtPTPEP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S11 | SQTVLsSGSDP | PhosphoSitePlus | |
| Y152 | IFITEyMSSGS | Pkinase | PhosphoSitePlus |
| S49 | EEEEEsEDESE | PhosphoSitePlus | |
| S2 | ____MsEGESQ | PhosphoSitePlus | |
| T225 | SVAPDtINNHV | PhosphoSitePlus | |
| S6 | TVLS | HPRD; SysPTM | |
| S422 | QEEVTsPVVPP | PhosphoSitePlus; HPRD; phosphoELM | |
| T8 | EGESQtVLSSG | PhosphoSitePlus; HPRD; SysPTM | |
| T433 | SVKTPtPEPAE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S2 | GESQ | HPRD; phosphoELM | |
| S14 | VLSSGsDPKVE | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| NRBP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000233557 | P432L | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 | ENSP00000233557 | Q73* | Greenman2007 | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000233557 | A326P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000369181 | Q73* | Greenman2007 | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000369181 | A326P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000369181 | P432L | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 |
| Differential expressed protein |
| NRBP_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NRBP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NRBP_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NRBP_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK2_HUMAN | NRBP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NRBP_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005938 | cell cortex | IEA | cellular_component |
| GO:0006888 | ER to Golgi vesicle-mediated transport | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0030027 | lamellipodium | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0042802 | identical protein binding | IEA | molecular_function |
| GO:0012505 | endomembrane system | IDA | cellular_component |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |