Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FAK2_HUMAN
Description:PTK2B protein tyrosine kinase 2 beta [Source:HGNC Symbol;Acc:9612]
Location:chr8 p21.2
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y722PSRPKyRPPPQPhosphoSitePlus
Y699ERNARyRTPKIPhosphoSitePlus
S530TLVLYsLQICKPkinase_TyrPhosphoSitePlus
T800DKSPLtPEKEVHPRD
S332APQALsIKTSSPhosphoSitePlus
S762PSPVNsLHTPPPhosphoSitePlus; HPRD
Y440FFGEVyEGVYTRegPhos
S2____MsGVSEPPhosphoSitePlus
S747GLCASsPTLTSPhosphoSitePlus
Y849EKEVGyLEFTGPhosphoSitePlus
Y881TDDLVyLNVMEPYK2RegPhos
T409EIPDEtLRRPGPhosphoSitePlus
S473KEKFMsEAVIMPkinase_TyrPhosphoSitePlus
T842DKSPLtPEKEVPhosphoSitePlus; HPRD; SysPTM
Y579IEDEDyYKASVautocatalysisRegPhos
Y579IEDEDyYKASVPYK2RegPhos
Y906LPPEGyVVVVKFocal_ATPhosphoSitePlus
Y756TSPMEyPSPVNPhosphoSitePlus; HPRD
S778VFKRHsMREEDPhosphoSitePlus
Y881TDDLVyLNVMEFocal_ATPhosphoSitePlus
S396LSESCsIESDIPhosphoSitePlus
Y683SLSDVyQMEKDPhosphoSitePlus
Y906LPPEGyVVVVKPTPN11HPRD
S758PMEYPsPVNSLPhosphoSitePlus; HPRD
Y580EDEDYyKASVTPkinase_TyrPhosphoSitePlus; SysPTM
S778VFKRHsMREEDPTK2BHPRD
S718PPPKPsRPKYRPhosphoSitePlus
T765VNSLHtPPLHRPhosphoSitePlus; HPRD; SysPTM
S375GEKRNsLPQIPPTK2BHPRD; SysPTM
S394SHLSEsCSIESPhosphoSitePlus; HPRD
Y792LDPMVyMNDKSHPRD
S752SPTLTsPMEYPPhosphoSitePlus
Y402IESDIyAEIPDPTK2BHPRD
Y579IEDEDyYKASVphosphoELM; RegPhos
S866RLGAQsIQPTAPhosphoSitePlus
Y580EDEDYyKASVTPYK2RegPhos; SysPTM
Y906LPPEGyVVVVKQ06124(SHP2RegPhos
Y834LDPMVyMNDKSPhosphoSitePlus; HPRD
S797YMNDKsPLTPEHPRD
T853GYLEFtGPPQKPhosphoSitePlus
S389LEARRsHLSESHPRD
Y864LPPEGyVVVVKPTPN11HPRD
S361GEHQGsLIIHPPhosphoSitePlus
S9VSEPLsRVKLGPhosphoSitePlus
Y573FGLSRyIEDEDPkinase_TyrPhosphoSitePlus
S559NILVAsPECVKPkinase_TyrPhosphoSitePlus
Y418PGGPQyGIAREPhosphoSitePlus
Y440FFGEVyEGVYTPkinase_TyrPhosphoSitePlus
Y579IEDEDyYKASVPkinase_TyrPhosphoSitePlus
S923RKLIGsVDDLLFocal_ATPhosphoSitePlus
S571GDFGLsRYIEDPkinase_TyrPhosphoSitePlus
Y839TDDLVyLNVMEPTK2BHPRD
S375GEKRNsLPQIPPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
Y881TDDLVyLNVMEPTK2BHPRD
T701NARYRtPKILEPhosphoSitePlus
T749CASSPtLTSPMPhosphoSitePlus
S583DYYKAsVTRLPPkinase_TyrPhosphoSitePlus
Y402IESDIyAEIPDPYK2phosphoELM; RegPhos
Y402IESDIyAEIPDSYKphosphoELM
Y580EDEDYyKASVTphosphoELM; RegPhos; SysPTM
Y402IESDIyAEIPDSykRegPhos
Y579IEDEDyYKASVPTK2BHPRD
S839YMNDKsPLTPEPhosphoSitePlus; HPRD; SysPTM
T15RVKLGtLRRPEPhosphoSitePlus
S399SCSIEsDIYAEPhosphoSitePlus; HPRD; SysPTM
Y580EDEDYyKASVTPTK2BHPRD; SysPTM
Y881TDDLVyLNVMEphosphoELM; RegPhos
Y402IESDIyAEIPDPhosphoSitePlus; phosphoELM; RegPhos
Y819QMVEDyQWLRQPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y906CQLPPEGyVVVVKNVPTPN11HPRD
Y864CQLPPEGyVVVVKNVPTPN11HPRD
Y402CSIESDIyAEIPDETPTPN12HPRD
Y579RYIEDEDyYKASVTRPTPN12HPRD
Y580YIEDEDYyKASVTRLPTPN12HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000342242R165CBIOMARTBreast Cancer21930507, 21930502
ENSP00000391995R165CBIOMARTBreast Cancer21930507, 21930502
ENSP00000380638E438QTCGAOvarian Cancer21720365, 18772890
ENSP00000427931R165CBIOMARTBreast Cancer21930507, 21930502
ENSP00000440926E438QTCGAOvarian Cancer21720365, 18772890
ENSP00000332816H447HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000332816E438QTCGAOvarian Cancer21720365, 18772890
ENSP00000440926H447HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000332816R165CBIOMARTBreast Cancer21930507, 21930502
ENSP00000380638H447HTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
FAK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FAK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FAK2_HUMANRBM12_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANMTCP1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANGDIB_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANKHDR2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANAKT3_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANKPYM_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANARAP1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANFAK2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
FAK2_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANKCIP2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANEZRI_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANIF2A_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANTGFI1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FAK2_HUMANRAB14_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANKCIP4_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANGDIR2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANRAB5B_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSTAP1_HUMANkinase -> substrateNetPath
FAK2_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANNUDT3_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANESR1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANNAR4_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANFAK1_HUMANkinase -> substrateHPRD; RegPhos
FAK2_HUMANKCIP1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCHMP3_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANTHIO_HUMANkinase -> substrateRobert H Newman (2013)
PTN11_HUMANFAK2_HUMANkinase -> substrateHPRD
FAK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANUBTD2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANM3K5_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANMAGD1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANRUVB1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSODC_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANLYPL1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANG3P_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANPPP5_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSUMO4_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANANXA2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANXIAP_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
LIMK2_HUMANFAK2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANFAK2_HUMANkinase -> substrateNetPath
ZAGL2_HUMANFAK2_HUMANkinase -> substrateRegPhos
CDK16_HUMANFAK2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANHSP72_HUMANkinase -> substrateRobert H Newman (2013)
PTN12_HUMANFAK2_HUMANphosphatase -> substrateHPRD
PTN11_HUMANFAK2_HUMANphosphatase -> substrateHPRD; NetPath
KPCA_HUMANFAK2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04912GnRH signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0030502negative regulation of bone mineralizationIEAbiological_process
GO:0006970response to osmotic stressIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0030838positive regulation of actin filament polymerizatiIMPbiological_process
GO:0005938cell cortexIEAcellular_component
GO:2000060positive regulation of protein ubiquitination invoIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0032403protein complex bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0043507positive regulation of JUN kinase activityIEAbiological_process
GO:0051000positive regulation of nitric-oxide synthase activIEAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0007229integrin-mediated signaling pathwayIMPbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0032863activation of Rac GTPase activityIEAbiological_process
GO:0048041focal adhesion assemblyIEAbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0043534blood vessel endothelial cell migrationIEAbiological_process
GO:2000379positive regulation of reactive oxygen species metIEAbiological_process
GO:0001556oocyte maturationIEAbiological_process
GO:0051279regulation of release of sequestered calcium ion iIEAbiological_process
GO:0042976activation of Janus kinase activityIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:2000114regulation of establishment of cell polarityIEAbiological_process
GO:0032960regulation of inositol trisphosphate biosynthetic IEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0002040sprouting angiogenesisIEAbiological_process
GO:0033209tumor necrosis factor-mediated signaling pathwayIMPbiological_process
GO:0030155regulation of cell adhesionIMPbiological_process
GO:0050848regulation of calcium-mediated signalingIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0071300cellular response to retinoic acidIMPbiological_process
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0030027lamellipodiumIDAcellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0051592response to calcium ionIEAbiological_process
GO:0010243response to organic nitrogenIEAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0045727positive regulation of translationIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0010226response to lithium ionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0045428regulation of nitric oxide biosynthetic processIEAbiological_process
GO:0030424axonIEAcellular_component
GO:0030279negative regulation of ossificationIEAbiological_process
GO:2000058regulation of protein ubiquitination involved in uIDAbiological_process
GO:0046777protein autophosphorylationTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0070098chemokine-mediated signaling pathwayIEAbiological_process
GO:0030826regulation of cGMP biosynthetic processIEAbiological_process
GO:0010752regulation of cGMP-mediated signalingIEAbiological_process
GO:0000302response to reactive oxygen speciesIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:2000249regulation of actin cytoskeleton reorganizationIEAbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0045860positive regulation of protein kinase activityIMPbiological_process
GO:2000538positive regulation of B cell chemotaxisIEAbiological_process
GO:0014009glial cell proliferationIEAbiological_process
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0045638negative regulation of myeloid cell differentiatioIMPbiological_process
GO:0010976positive regulation of neuron projection developmeIMPbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005925focal adhesionIEAcellular_component
GO:0031175neuron projection developmentIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:00434233-phosphoinositide-dependent protein kinase bindinIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0002315marginal zone B cell differentiationIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0046330positive regulation of JNK cascadeIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0010758regulation of macrophage chemotaxisIEAbiological_process
GO:0043267negative regulation of potassium ion transportIDAbiological_process
GO:0006950response to stressTASbiological_process
GO:0043149stress fiber assemblyIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007166cell surface receptor signaling pathwayIMPbiological_process
GO:0010595positive regulation of endothelial cell migrationIEAbiological_process
GO:0045453bone resorptionIEAbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0030426growth coneIEAcellular_component
GO:0045471response to ethanolIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0001954positive regulation of cell-matrix adhesionIMPbiological_process
GO:0009725response to hormone stimulusIEAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0048010vascular endothelial growth factor receptor signalIEAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0007172signal complex assemblyIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0051591response to cAMPIEAbiological_process
GO:0007015actin filament organizationIEAbiological_process