Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FGFR1_HUMAN
Description:fibroblast growth factor receptor 1 [Source:HGNC Symbol;Acc:3688]
Location:chr8 p11.22
Node attribute:substrate; kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y766TSNQEyLDLSMQ15464(SHBRegPhos
Y766TSNQEyLDLSMPhosphoSitePlus; phosphoELM
Y585GLEYCyNPSHNFGFR1phosphoELM; RegPhos
Y654HHIDYyKKTTNphosphoELM
Y730CTNELyMMMRDphosphoELM
S450RPSRLsSSGTPPhosphoSitePlus
Y766TSNQEyLDLSMFGFR1phosphoELM; RegPhos
Y585GLEYCyNPSHNphosphoELM
Y654HHIDYyKKTTNautocatalysis RegPhos
Y730CTNELyMMMRDPkinase_TyrPhosphoSitePlus
Y654HHIDYyKKTTNFGFR1phosphoELM; RegPhos
Y653IHHIDyYKKTTHPRD; phosphoELM
S451PSRLSsSGTPMPhosphoSitePlus
Y651IHHIDyYKKTTHPRD
Y307PDNLPyVQILKI-setPhosphoSitePlus
Y605LVSCAyQVARGPkinase_TyrPhosphoSitePlus
Y583PPGLEyCYNPSPkinase_TyrPhosphoSitePlus
Y585GLEYCyNPSHNPkinase_TyrPhosphoSitePlus
S91VEVQDsVPADSI-setPhosphoSitePlus
S447LLVRPsRLSSSPhosphoSitePlus
Y766TSNQEyLDLSMautocatalysisRegPhos
Y586LFDRIyTHQSDHPRD
Y730CTNELyMMMRDFGFR1phosphoELM; RegPhos
Y677LFDRIyTHQSDPkinase_TyrPhosphoSitePlus
Y463AGVSEyELPEDPhosphoSitePlus; phosphoELM
Y677TSNQEyLDLSMSHBHPRD
Y583PPGLEyCYNPSFGFR1phosphoELM; RegPhos
Y588LFDRIyTHQSDHPRD
Y610LGGSPyPGVPVHPRD
Y613ARGMEyLASKKPkinase_TyrPhosphoSitePlus
Y677LFDRIyTHQSDRegPhos
S602SKDLVsCAYQVPkinase_TyrPhosphoSitePlus
S452SRLSSsGTPMLPhosphoSitePlus
Y677LFDRIyTHQSDQ15464(SHBRegPhos
Y764TSNQEyLDLSMSHBHPRD
S410KSDFHsQMAVHPhosphoSitePlus
Y699LGGSPyPGVPVHPRD
Y280FMCKVySDPQPI-setPhosphoSitePlus
Y583PPGLEyCYNPSphosphoELM
Y653IHHIDyYKKTTPkinase_TyrPhosphoSitePlus
Y701LGGSPyPGVPVRegPhos
Y154MPVAPyWTSPEPhosphoSitePlus
Y154MPVAPyWTSPEFGFR1phosphoELM; RegPhos
Y572GNLREyLQARRPkinase_TyrPhosphoSitePlus
S439SASMNsGVLLVPhosphoSitePlus
Y562IHHIDyYKKTTHPRD
T428LRRQVtVSADSPhosphoSitePlus
Y612LGGSPyPGVPVHPRD
Y675LFDRIyTHQSDHPRD
S777PLDQYsPSFPDPhosphoSitePlus
T454LSSSGtPMLAGPhosphoSitePlus
Y307PDNLPyVQILKFGFR1phosphoELM; RegPhos
Y653IHHIDyYKKTTFGFR1phosphoELM; RegPhos
Y654HHIDYyKKTTNPkinase_TyrPhosphoSitePlus
Y280FMCKVySDPQPFGFR1phosphoELM; RegPhos
Y564IHHIDyYKKTTHPRD
Y776MPLDQySPSFPPhosphoSitePlus
Y463AGVSEyELPEDFGFR1phosphoELM; RegPhos
Y605LVSCAyQVARGFGFR1phosphoELM; RegPhos
Y675TSNQEyLDLSMSHBHPRD

Dephosphorylation site
FGFR1_HUMAN do not have dephosphorylation site.

Mutation site
FGFR1_HUMAN do not have mutation site.

Differential expressed protein
FGFR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FGFR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGF1_HUMANFGFR1_HUMANligand -> receptorHPMR
FGF8_HUMANFGFR1_HUMANligand -> receptorHPMR
FGF5_HUMANFGFR1_HUMANligand -> receptorHPMR
FGF4_HUMANFGFR1_HUMANligand -> receptorHPMR
FGF3_HUMANFGFR1_HUMANligand -> receptorHPMR
FGF23_HUMANFGFR1_HUMANligand -> receptorHPMR
FGFR1_HUMANEXOS5_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANFGFR1_HUMANkinase -> substrateRegPhos
FGFR1_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANRS10_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANFGFR1_HUMANkinase -> substrateRegPhos
FGFR1_HUMANANXA2_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANRAGE_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANLSR_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANSRC8_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
SHB_HUMANFGFR1_HUMANkinase -> substrateHPRD
FGFR1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANPLCG1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FGFR1_HUMANXPR1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANKS6A3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FGFR1_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANBCAR1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FGFR1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANHNRPQ_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FGFR1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR1_HUMANDDX6_HUMANkinase -> substrateRobert H Newman (2013)
FGF1_HUMANFGFR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction
hsa05215Prostate cancer
hsa05218Melanoma
hsa04010MAPK signaling pathway
hsa05200Pathways in cancer
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0021847ventricular zone neuroblast divisionIEAbiological_process
GO:0006468protein phosphorylationNASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0048469cell maturationIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0048705skeletal system morphogenesisTASbiological_process
GO:0060665regulation of branching involved in salivary glandIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0016477cell migrationTASbiological_process
GO:0005007fibroblast growth factor-activated receptor activiIEAmolecular_function
GO:0005576extracellular regionNAScellular_component
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0035607fibroblast growth factor receptor signaling pathwaIEAbiological_process
GO:0008201heparin bindingIDAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0010518positive regulation of phospholipase activityTASbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaTASbiological_process
GO:0042473outer ear morphogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0090080positive regulation of MAPKKK cascade by fibroblasIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0001759organ inductionIEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0045595regulation of cell differentiationTASbiological_process
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0048339paraxial mesoderm developmentIEAbiological_process
GO:0048699generation of neuronsIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaIPIbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0048762mesenchymal cell differentiationIEAbiological_process
GO:0001501skeletal system developmentTASbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0060484lung-associated mesenchyme developmentIEAbiological_process
GO:0007435salivary gland morphogenesisIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007605sensory perception of soundIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0045787positive regulation of cell cycleIEAbiological_process
GO:0060117auditory receptor cell developmentIEAbiological_process
GO:0000165MAPK cascadeTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0021769orbitofrontal cortex developmentIEAbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0048378regulation of lateral mesodermal cell fate specifiIEAbiological_process
GO:0045666positive regulation of neuron differentiationIMPbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0001764neuron migrationTASbiological_process
GO:0043009chordate embryonic developmentTASbiological_process
GO:0017134fibroblast growth factor bindingIDAmolecular_function
GO:0007420brain developmentIEAbiological_process
GO:0010863positive regulation of phospholipase C activityIDAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0002062chondrocyte differentiationIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0060445branching involved in salivary gland morphogenesisIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIMPbiological_process
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0030901midbrain developmentIEAbiological_process
GO:0042474middle ear morphogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0010976positive regulation of neuron projection developmeIEAbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeIEAbiological_process