Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TBK1_HUMAN
Description:TANK-binding kinase 1 [Source:HGNC Symbol;Acc:11584]
Location:chr12 q14.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T664PQKMFtASSGIPhosphoSitePlus
S509KLLRLsSSQGTHPRD
Y354NQELIyEGRRLPhosphoSitePlus
Y577ERRLAyNEEQIPhosphoSitePlus
Y174QFVSLyGTEEYPkinasePhosphoSitePlus
S716LERFGsLTMDGPhosphoSitePlus; HPRD; SysPTM
Y179YGTEEyLHPDMPkinasePhosphoSitePlus
T672SGIKHtMTPIYHPRD
Y153DGQSVyKLTDFPkinasePhosphoSitePlus
S172DEQFVsLYGTEHPRD; phosphoELM
T503ISDIHtKLLRLPhosphoSitePlus
S172DEQFVsLYGTEPkinasePhosphoSitePlus

Dephosphorylation site
TBK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000329967F663LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000329967G410RHPIColorectal Cancer17344846
ENSP00000329967A535TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000329967G410RGreenman2007Intestines Cancer17344846, 18428421
ENSP00000329967D13EBIOMARTBreast Cancer21930507, 21930502
ENSP00000329967I582FBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000329967D296HGreenman2007, HPIBreast Cancer15908952, 17344846, 18428421
ENSP00000329967P675LCOSMICLung Cancer20668451
ENSP00000329967R525STCGAOvarian Cancer21720365, 18772890
ENSP00000329967C728SBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000329967*730YCOSMICLung Cancer18948947

Differential expressed protein
TBK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TBK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TBK1_HUMANIRF5_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANHDAC3_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANPSPC1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANSUMO4_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANIKBA_HUMANkinase -> substrateHPRD; RegPhos; NetPath
TBK1_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANCHIP_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANDNM3A_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANNAR4_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMAN1433E_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANECHB_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANHSPB1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANDDX25_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANCERK1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANTF65_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
TBK1_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANIRF3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
TBK1_HUMANASCC1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05160Hepatitis C
hsa04623Cytosolic DNA-sensing pathway
hsa05162Measles
hsa05164Influenza A
hsa04620Toll-like receptor signaling pathway
hsa05168Herpes simplex infection
hsa04622RIG-I-like receptor signaling pathway
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0045087innate immune responseTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0045359positive regulation of interferon-beta biosynthetiIEAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0002218activation of innate immune responseIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0032727positive regulation of interferon-alpha productionIDAbiological_process
GO:0050830defense response to Gram-positive bacteriumIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0032606type I interferon productionTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0009615response to virusTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0032480negative regulation of type I interferon productioTASbiological_process
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0051219phosphoprotein bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0032728positive regulation of interferon-beta productionIDAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23