| UniProt/SwissProt ID: | PKN3_HUMAN |
| Description: | protein kinase N3 [Source:HGNC Symbol;Acc:17999] |
| Location: | chr9 q34.11 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T508 | LGEEMtPPPKP | PhosphoSitePlus; HPRD; SysPTM | |
| T722 | STFCGtPEFLA | HPRD; phosphoELM; SysPTM | |
| T716 | GFGDRtSTFCG | HPRD | |
| T718 | GDRTStFCGTP | Pkinase_AGC | PhosphoSitePlus |
| T860 | LPPALtPPAPH | HPRD; phosphoELM; SysPTM | |
| S544 | TRRGPsPPASP | PKN3 | HPRD; SysPTM |
| T820 | QPFFRtTNWQA | PhosphoSitePlus | |
| T492 | ASDPAtPSNFL | PhosphoSitePlus | |
| T718 | GDRTStFCGTP | HPRD; phosphoELM | |
| T527 | PTSEEtPRTKR | PhosphoSitePlus | |
| T550 | PPASPtRKPPR | PhosphoSitePlus; phosphoELM | |
| S544 | TRRGPsPPASP | PhosphoSitePlus; phosphoELM; SysPTM | |
| T860 | LPPALtPPAPH | Pkinase_C | PhosphoSitePlus; SysPTM |
| T722 | STFCGtPEFLA | Pkinase_AGC | PhosphoSitePlus; SysPTM |
| S717 | FGDRTsTFCGT | Pkinase_AGC | PhosphoSitePlus |
| S307 | AALASsPSEGW | PhosphoSitePlus; HPRD; SysPTM | |
| S309 | LASSPsEGWLR | HPRD; phosphoELM | |
| T550 | PPASPtRKPPR | PKN3 | HPRD |
| T523 | LPQEPtSEETP | HPRD | |
| S548 | PSPPAsPTRKP | PhosphoSitePlus; HPRD; phosphoELM | |
| T716 | GFGDRtSTFCG | Pkinase_AGC | PhosphoSitePlus |
| S299 | AVPGRsPAAAL | PhosphoSitePlus | |
| Dephosphorylation site |
| PKN3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000291906 | G713R | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000291906 | S307I | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 |
| Differential expressed protein |
| PKN3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PKN3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PKN3_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN3_HUMAN | PKN3_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05132 | Salmonella infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005794 | Golgi apparatus | TAS | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004697 | protein kinase C activity | IEA | molecular_function |
| GO:0010631 | epithelial cell migration | IDA | biological_process |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |