Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:YES_HUMAN
Description:v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 [Source:HGNC Symbol;Acc:12841]
Location:chr18 p11.32
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y223DNGGYyITTRAphosphoELM
Y426IEDNEyTARQGphosphoELM; SysPTM
T27PEPVStSVSHYHPRD
Y426IEDNEyTARQGYesphosphoELM; RegPhos; SysPTM
Y345SEEPIyIVTEFPkinase_TyrPhosphoSitePlus
Y426IEDNEyTARQGYESRegPhos; SysPTM
Y537ATEPQyQPGEHPRD; phosphoELM; SysPTM
S26TPEPVsTSVSHPhosphoSitePlus; HPRD
Y141TGKNGyIPSNYSH3_1PhosphoSitePlus
Y32TSVSHyGAEPTPhosphoSitePlus; HPRD; phosphoELM
Y426IEDNEyTARQGYES1HPRD; SysPTM
S187FLVREsETTKGSH2PhosphoSitePlus
T190RESETtKGAYSSH2PhosphoSitePlus
S11SKENKsPAIKYPhosphoSitePlus; HPRD; SysPTM
S45SPCPSsSAKGTPhosphoSitePlus; HPRD
Y16SPAIKyRPENTPhosphoSitePlus
S40EPTTVsPCPSSPhosphoSitePlus; HPRD; SysPTM
Y146YIPSNyVAPADPhosphoSitePlus
T427EDNEYtARQGAPkinase_TyrPhosphoSitePlus
Y223DNGGYyITTRASH2PhosphoSitePlus
T531LEDYFtATEPQPhosphoSitePlus
Y426IEDNEyTARQGautocatalysisRegPhos; SysPTM
T226GYYITtRAQFDSH2PhosphoSitePlus
S195TKGAYsLSIRDHPRD; SysPTM
Y426IEDNEyTARQGPkinase_TyrPhosphoSitePlus; SysPTM
Y537ATEPQyQPGENPhosphoSitePlus; RegPhos; SysPTM
S111TTEDLsFKKGEHPRD; SysPTM
Y446PEAALyGRFTIPkinase_TyrPhosphoSitePlus
Y336KLVPLyAVVSEPkinase_TyrPhosphoSitePlus
Y194TTKGAySLSIRSH2PhosphoSitePlus; SysPTM
Y222LDNGGyYITTRSH2PhosphoSitePlus
T21YRPENtPEPVSPhosphoSitePlus; HPRD
T533DYFTAtEPQYQPhosphoSitePlus
S195TKGAYsLSIRDSH2PhosphoSitePlus; SysPTM
Y194TTKGAySLSIRHPRD; RegPhos; SysPTM
S30VSTSVsHYGAEPhosphoSitePlus; HPRD
Y446PEAALyGRFTIHPRD; phosphoELM
S28EPVSTsVSHYGPhosphoSitePlus; HPRD
S144NGYIPsNYVAPSH3_1PhosphoSitePlus
Y100IFVALyDYEARSH3_1PhosphoSitePlus
S197GAYSLsIRDWDSH2PhosphoSitePlus
Y222LDNGGyYITTRphosphoELM; RegPhos
S44VSPCPsSSAKGHPRD; phosphoELM
S111TTEDLsFKKGESH3_1PhosphoSitePlus; SysPTM
Y159QAEEWyFGKMGSH2PhosphoSitePlus

Dephosphorylation site
YES_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324740W158LDing2008Lung Cancer18948947

Differential expressed protein
YES_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y32VSTSVSHyGAEPTTVcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
YES_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANYES_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANENOA_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANNUDT4_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANUBTD2_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANCDN1B_HUMANkinase -> substrateHPRD
YES_HUMANRAP1A_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANGELS_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANHSP7C_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMAN1433Z_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANTHIO_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANFYN_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANTF65_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANTRI29_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANYES_HUMANkinase -> substrateRegPhos
YES_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANKPYM_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANYES_HUMANkinase -> substrateHPRD; RegPhos
YES_HUMANMOES_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANG3BP1_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANMCP_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04530Tight junction
hsa04520Adherens junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031295T cell costimulationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0043114regulation of vascular permeabilityTASbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004715non-membrane spanning protein tyrosine kinase actiTASmolecular_function
GO:0005794Golgi apparatusIDAcellular_component
GO:0006464cellular protein modification processTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0015758glucose transportIEAbiological_process
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0050900leukocyte migrationTASbiological_process
GO:0044325ion channel bindingIPImolecular_function
GO:0005154epidermal growth factor receptor bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0005815microtubule organizing centerIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0019899enzyme bindingIPImolecular_function


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