Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KS6A4_HUMAN
Description:ribosomal protein S6 kinase, 90kDa, polypeptide 4 [Source:HGNC Symbol;Acc:10433]
Location:chr11 q13.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S360IFQGYsFVAPSp38a(MAPK14RegPhos
S360IFQGYsFVAPSRegPhos
S721GFFLKsVENAPPhosphoSitePlus
S196KERTFsFCGTIp38aRegPhos
S360IFQGYsFVAPSPkinase_CPhosphoSitePlus
T194EEKERtFSFCGPkinasePhosphoSitePlus
S343LEPVYsPPGSPp38a(MAPK14RegPhos
S681DGSARsSPPLRHPRD; phosphoELM; RegPhos
T41LKVLGtGAYGKPkinasePhosphoSitePlus
T568GVPMQtPCFTLp38a(MAPK14RegPhos
Y359RIFQGySFVAPHPRD
T376NNAVMtDGLEAPhosphoSitePlus
Y342RLEPVySPPGSPkinase_CPhosphoSitePlus
S360IFQGYsFVAPSMAP2K1HPRD; RegPhos
S196KERTFsFCGTIMAP2K1HPRD; RegPhos
T568GVPMQtPCFTLMAPK14HPRD; phosphoELM
S347YSPPGsPPPGDMAPK14HPRD; phosphoELM; SysPTM
S196KERTFsFCGTIRegPhos
S343LEPVYsPPGSPMAP2K1HPRD; RegPhos
S196KERTFsFCGTIMAPK14HPRD; phosphoELM
S365SFVAPsILFDHPkinase_CPhosphoSitePlus
S196KERTFsFCGTIp38a(MAPK14RegPhos
Y44LGTGAyGKVFLPkinasePhosphoSitePlus
S343LEPVYsPPGSPPkinase_CPhosphoSitePlus
S29HEEKVsVENFEPhosphoSitePlus
T568GVPMQtPCFTLMAP2K1HPRD; RegPhos
S678WLQDGsARSSPPhosphoSitePlus; HPRD; SysPTM
T568GVPMQtPCFTLPkinasePhosphoSitePlus
S745ASRRGsPAPANPhosphoSitePlus; HPRD; SysPTM
S360IFQGYsFVAPSp38aRegPhos
S343LEPVYsPPGSPp38aRegPhos
T687SPPLRtPDVLEPhosphoSitePlus; phosphoELM; RegPhos
Y141AEVRVyGGEIVPkinasePhosphoSitePlus
S693PDVLEsSGPAVHPRD
S360IFQGYsFVAPSMAPK14HPRD; phosphoELM
T687SPPLRtPDVLERPS6KA4HPRD
S324RPQIRsELDVGPkinase_CPhosphoSitePlus
S343LEPVYsPPGSPMAPK14HPRD; phosphoELM
Y359RIFQGySFVAPPkinase_CPhosphoSitePlus
S365SFVAPsILFDHHPRD
S196KERTFsFCGTIPkinasePhosphoSitePlus
S634REGRFsLDGEAPkinasePhosphoSitePlus; SysPTM
S682GSARSsPPLRTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S343LEPVYsPPGSPRegPhos
S347YSPPGsPPPGDMAP2K1HPRD; RegPhos; SysPTM
T542LYADDtPGAPVPkinasePhosphoSitePlus
T568GVPMQtPCFTLRegPhos
S347YSPPGsPPPGDp38aRegPhos; SysPTM
S347YSPPGsPPPGDRegPhos; SysPTM
T568GVPMQtPCFTLp38aRegPhos
S737KQKLRsATASRPhosphoSitePlus; HPRD; RegPhos; SysPTM
S347YSPPGsPPPGDPkinase_CPhosphoSitePlus; SysPTM
S347YSPPGsPPPGDp38a(MAPK14RegPhos; SysPTM
S634REGRFsLDGEAHPRD; SysPTM

Dephosphorylation site
KS6A4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000333896S236LGreenman2007Breast Cancer15908952, 17344846, 18428421
ENSP00000333896S236LHPIbreast ductal carcinoma17344846
ENSP00000333896T542MCOSMICBreast Cancer20668451

Differential expressed protein
KS6A4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KS6A4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A4_HUMANATF1_HUMANkinase -> substrateHPRD; RegPhos
KS6A4_HUMANNASP_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANLUZP1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANARI3A_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANPSA7L_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANTBX20_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANKS6A4_HUMANkinase -> substrateHPRD
KS6A4_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANPO6F1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANRUVB1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANRBM38_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANSAFB2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANKS6A4_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)
KS6A4_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANSUFU_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANTF65_HUMANkinase -> substrateRegPhos
KS6A4_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos
KS6A4_HUMANHMGN1_HUMANkinase -> substrateHPRD; RegPhos
KS6A4_HUMANENOA_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANZMYM3_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKS6A4_HUMANkinase -> substrateRegPhos
KS6A4_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K1_HUMANKS6A4_HUMANkinase -> substrateRegPhos
KS6A4_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANATF4_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0001818negative regulation of cytokine productionTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0032793positive regulation of CREB transcription factor aTASbiological_process
GO:0043988histone H3-S28 phosphorylationIMPbiological_process
GO:0004711ribosomal protein S6 kinase activityNASmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0033129positive regulation of histone phosphorylationIMPbiological_process
GO:0070498interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0048273mitogen-activated protein kinase p38 bindingIGImolecular_function
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0035066positive regulation of histone acetylationIMPbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0004674protein serine/threonine kinase activityIMPmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016572histone phosphorylationTASbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0043987histone H3-S10 phosphorylationIMPbiological_process


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