Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK14_HUMAN
Description:mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:6876]
Location:chr6 p21.31
Node attribute:PPI(source); PPI(target); substrate; kinase; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y182DEMTGyVATRWMAP2K6HPRD; RegPhos; SysPTM
Y323PVADPyDQSFEPhosphoSitePlus
T175GLARHtDDEMTHPRD
T180TDDEMtGYVATHPRD; phosphoELM; RegPhos; SysPTM
T180TDDEMtGYVATMAP2K6HPRD; phosphoELM; RegPhos; SysPTM
T16QELNKtIWEVPPhosphoSitePlus; HPRD
T180TDDEMtGYVATPkinasePhosphoSitePlus; SysPTM
S56AVKKLsRPFQSPkinasePhosphoSitePlus
Y182DEMTGyVATRWPkinasePhosphoSitePlus; SysPTM
Y9ERPTFyRQELNHPRD
Y323PVADPyDQSFEZAP70phosphoELM; RegPhos
T175GLARHtDDEMTPkinasePhosphoSitePlus
T263YIQSLtQMPKMHPRD; phosphoELM; RegPhos
Y182DEMTGyVATRWMAP2K3RegPhos; SysPTM
T298SDKRItAAQALHPRD
S2____MsQERPTPhosphoSitePlus
S28RYQNLsPVGSGPkinasePhosphoSitePlus
T185TGYVAtRWYRAPkinasePhosphoSitePlus
T241MRLTGtPPAYLHPRD
S2ERPTHPRD
Y182DEMTGyVATRWRETHPRD; RegPhos; SysPTM
T263YIQSLtQMPKMPkinasePhosphoSitePlus
T180TDDEMtGYVATMAP2K_groupphosphoELM; RegPhos; SysPTM
T241LRLVGtPGAELPkinasePhosphoSitePlus
Y182DEMTGyVATRWHPRD; phosphoELM; RegPhos; SysPTM
T180TDDEMtGYVATMAP2K3HPRD; RegPhos; SysPTM
Y182DEMTGyVATRWMAP2K_groupphosphoELM; SysPTM
T123KCQKLtDDHVQPkinasePhosphoSitePlus

Dephosphorylation site
MK14_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000229795N278ITCGAOvarian Cancer21720365, 18772890
ENSP00000229795P322RGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000229795A51VGreenman2007Gastric Cancer17344846, 18428421
ENSP00000229794P322RGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000229794A51VGreenman2007, HPIGastric Cancer17344846, 18428421

Differential expressed protein
MK14_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MK14_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANP53_HUMANkinase -> substrateKEGG; HPRD
MK14_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANHNF4A_HUMANkinase -> substrateHPRD
MK14_HUMANMAX_HUMANkinase -> substrateKEGG; HPRD
MK14_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANNCF1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANPRGC1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK14_HUMANKSYK_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANELK1_HUMANkinase -> substrateKEGG; HPRD; NetPath; Robert H Newman (2013)
MK14_HUMANMPIP2_HUMANkinase -> substrateKEGG
MK14_HUMANMAPK2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK14_HUMANPA24A_HUMANkinase -> substrateHPRD
MK14_HUMANMEF2A_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK14_HUMANPAK6_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANK2C8_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK14_HUMANMPIP3_HUMANkinase -> substrateHPRD
MK14_HUMANSL9A1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MP2K3_HUMANMK14_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK14_HUMANDDIT3_HUMANkinase -> substrateKEGG; HPRD
MK14_HUMANSMAD3_HUMANkinase -> substrateHPRD
MK14_HUMANCDX2_HUMANkinase -> substrateHPRD
MK14_HUMANNUP62_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANMK14_HUMANkinase -> substrateNetPath
MK14_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANKHDR1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANSKAP1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANBFAR_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANZNHI1_HUMANkinase -> substrateHPRD
MK14_HUMANNFH_HUMANkinase -> substrateKEGG
MK14_HUMANEEA1_HUMANkinase -> substrateHPRD
MK14_HUMANCASP3_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANGEMI7_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANJUNB_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK14_HUMANELK4_HUMANkinase -> substrateKEGG
MK14_HUMANSTAT4_HUMANkinase -> substrateHPRD; NetPath
RET_HUMANMK14_HUMANkinase -> substrateHPRD; RegPhos
MK14_HUMANEF2K_HUMANkinase -> substrateHPRD
MK14_HUMANKS6A4_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)
MK14_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANM4K2_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANESR1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK14_HUMANNFL_HUMANkinase -> substrateKEGG
MK14_HUMANJDP2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK14_HUMANATF2_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
MK14_HUMANMAFA_HUMANkinase -> substrateHPRD
MK14_HUMANNFAC4_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK14_HUMANRBM12_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMAN4EBP1_HUMANkinase -> substrateHPRD
MK14_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANKS6A5_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAP70_HUMANMK14_HUMANkinase -> substrateKEGG; RegPhos; Robert H Newman (2013)
MK14_HUMANRBNS5_HUMANkinase -> substrateHPRD
MK14_HUMANCREB1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANCASP8_HUMANkinase -> substrateRobert H Newman (2013)
MP2K6_HUMANMK14_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK14_HUMANSIK1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANTAB1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMK14_HUMANkinase -> substrateRegPhos
MK14_HUMANMAPK3_HUMANkinase -> substrateKEGG
MK14_HUMANTF65_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANPTN7_HUMANkinase -> substrateHPRD
MK14_HUMANELK3_HUMANkinase -> substrateHPRD
MK14_HUMANNFM_HUMANkinase -> substrateKEGG
MK14_HUMANGRK5_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANMAPK5_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)
MK14_HUMANMEF2C_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)
MK14_HUMANNCOA3_HUMANkinase -> substrateHPRD
PTN7_HUMANMK14_HUMANphosphatase -> substrateKEGG
DUS14_HUMANMK14_HUMANphosphatase -> substrateKEGG
CDC42_HUMANMK14_HUMANotherKEGG
MK14_HUMANFOS_HUMANotherKEGG
MP2K3_HUMANMK14_HUMANotherKEGG
MK14_HUMANNFAT5_HUMANotherKEGG
MK14_HUMANGROA_HUMANTF -> target geneKEGG
MK14_HUMANIL8_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04912GnRH signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa05145Toxoplasmosis
hsa05142Chagas disease (American trypanosomiasis)
hsa04670Leukocyte transendothelial migration
hsa05131Shigellosis
hsa04723Retrograde endocannabinoid signaling
hsa05164Influenza A
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04621NOD-like receptor signaling pathway
hsa04728Dopaminergic synapse
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa05132Salmonella infection
hsa04722Neurotrophin signaling pathway
hsa05169Epstein-Barr virus infection
hsa05152Tuberculosis
hsa04914Progesterone-mediated oocyte maturation
hsa04010MAPK signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05133Pertussis
hsa04380Osteoclast differentiation
hsa05160Hepatitis C
hsa05140Leishmaniasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006928cellular component movementTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0019395fatty acid oxidationIEAbiological_process
GO:0048010vascular endothelial growth factor receptor signalIMPbiological_process
GO:2000379positive regulation of reactive oxygen species metIMPbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0042307positive regulation of protein import into nucleusIEAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0000187activation of MAPK activityTASbiological_process
GO:0042770signal transduction in response to DNA damageIMPbiological_process
GO:0051090regulation of sequence-specific DNA binding transcTASbiological_process
GO:0004707MAP kinase activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0032495response to muramyl dipeptideIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0005623cellIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0051525NFAT protein bindingIEAmolecular_function
GO:0071479cellular response to ionizing radiationIMPbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0000077DNA damage checkpointIEAbiological_process
GO:00709353'-UTR-mediated mRNA stabilizationTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0006006glucose metabolic processIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0090400stress-induced premature senescenceIMPbiological_process
GO:0042692muscle cell differentiationTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0035924cellular response to vascular endothelial growth fIMPbiological_process
GO:0007519skeletal muscle tissue developmentIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0000922spindle poleIEAcellular_component
GO:0006935chemotaxisTASbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0030316osteoclast differentiationIEAbiological_process
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0002062chondrocyte differentiationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004708MAP kinase kinase activityTASmolecular_function
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0051146striated muscle cell differentiationIEAbiological_process
GO:0006950response to stressIDAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0045648positive regulation of erythrocyte differentiationIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0000902cell morphogenesisIEAbiological_process