Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PIM1_HUMAN
Description:pim-1 oncogene [Source:HGNC Symbol;Acc:8986]
Location:chr6 p21.2
Node attribute:substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S137GPLLGsGGFGSPkinase_CAMKPhosphoSitePlus
S352RQRVSsECQHLPkinase_CAMKPhosphoSitePlus
T114NDLHAtKLAPGPhosphoSitePlus
S280LIDFGsGALLKPkinase_CAMKPhosphoSitePlus
S189LKKVSsGFSGVPkinase_CAMKPhosphoSitePlus
S99LSKINsLAHLRPhosphoSitePlus

Dephosphorylation site
PIM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362608N178STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000362608Y53HGreenman2007Intestines Cancer17344846, 18428421

Differential expressed protein
PIM1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PIM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PIM1_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANCDN1A_HUMANkinase -> substrateHPRD; RegPhos
PIM1_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANMPIP1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
PIM1_HUMANF110D_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANRP9_HUMANkinase -> substrateRegPhos
PIM1_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANSP100_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANLZTL1_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANPIM1_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANRAP1A_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANBAD_HUMANkinase -> substrateRegPhos
PIM1_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANT22D3_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANGAGC1_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
STAT1_HUMANPIM1_HUMANTF -> target geneKEGG
STAT3_HUMANPIM1_HUMANTF -> target geneTRANSFAC
STAT4_HUMANPIM1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05221Acute myeloid leukemia
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0007275multicellular organismal developmentTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0030145manganese ion bindingIDAmolecular_function
GO:0008283cell proliferationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0031659positive regulation of cyclin-dependent protein kiIDAbiological_process
GO:0046777protein autophosphorylationIMPbiological_process
GO:0007049cell cycleIEAbiological_process


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