Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHB1_HUMAN
Description:EPH receptor B1 [Source:HGNC Symbol;Acc:3392]
Location:chr3 q22.2
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S395RVSISsLWAHTfn3PhosphoSitePlus
S979VQISQsPTAMAPhosphoSitePlus
Y928IKMVQyRDSFLautocatalysisRegPhos
T599YIDPFtYEDPNPhosphoSitePlus
S774LQDDTsDPTYTPkinase_TyrPhosphoSitePlus
T981ISQSPtAMA__PhosphoSitePlus
S766SDFGLsRYLQDPkinase_TyrPhosphoSitePlus
Y594PGMKIyIDPFTPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
Y798PEAIAyRKFTSPkinase_TyrPhosphoSitePlus
Y575SKEAVySDKLQDAP10PhosphoSitePlus
Y778TSDPTyTSSLGPkinase_TyrPhosphoSitePlus
Y928IKMVQyRDSFLEPHB1HPRD
Y778TSDPTyTSSLGautocatalysis RegPhos
Y594PGMKIyIDPFTautocatalysisRegPhos; SysPTM
Y594PGMKIyIDPFTEphB1RegPhos; SysPTM
S754NILVNsNLVCKPkinase_TyrPhosphoSitePlus
S968KKILNsIHSMRRegPhos
S761LVCKVsDFGLSPkinase_TyrPhosphoSitePlus
Y600IDPFTyEDPNEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S968KKILNsIHSMRSAM_1PhosphoSitePlus
Y778TSDPTyTSSLGphosphoELM; RegPhos
Y928IKMVQyRDSFLEphB1RegPhos
Y634EFGEVyKGRLKPkinase_TyrPhosphoSitePlus
Y928IKMVQyRDSFLSAM_1PhosphoSitePlus
T777DTSDPtYTSSLPkinase_TyrPhosphoSitePlus
Y594PGMKIyIDPFTEPHB1HPRD; SysPTM
Y582DKLQHySTGRGDAP10PhosphoSitePlus
Y600IDPFTyEDPNEautocatalysis RegPhos; SysPTM

Dephosphorylation site
EPHB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381097A176TTCGAOvarian Cancer21720365, 18772890
ENSP00000381097R79WCOSMICMelanoma19718025
ENSP00000381097M591TCOSMICHead and Neck Cancer21798893
ENSP00000381097A176TCOSMICOvarian Cancer21720365
ENSP00000381097I719VHPIGastric Cancer17344846
ENSP00000381097P167LCOSMICLung Cancer20668451
ENSP00000381097N753STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000381097A204SCOSMICBreast Cancer20668451
ENSP00000381097G811ECOSMICMelanoma19718025
ENSP00000381097R304QCOSMICHead and Neck Cancer21798893
ENSP00000381097R327HCOSMICOvarian Cancer21720365
ENSP00000381097R170LCOSMICHead and Neck Cancer21798893
ENSP00000381097D771NCOSMICMelanoma19718025
ENSP00000381097S707THPIOvarian Cancer17344846
ENSP00000381097R327HTCGAOvarian Cancer21720365, 18772890
ENSP00000381097R743QHPIGastric Cancer17344846
ENSP00000381097N461SCOSMICGastric Cancer21097718
ENSP00000381097T387MCOSMICOvarian Cancer20668451
ENSP00000381097T117NCOSMICOvarian Cancer21720365
ENSP00000381097M1KCOSMICOvarian Cancer21720365
ENSP00000381097W919*COSMICMelanoma19718025
ENSP00000381097R364LCOSMICLung Cancer20668451
ENSP00000381097Y734FCOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000381097Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.4515169874

Hyperphosphorylation site
EPHB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNB1_HUMANEPHB1_HUMANligand -> receptorHPMR
EFNB2_HUMANEPHB1_HUMANligand -> receptorHPMR
EFNA3_HUMANEPHB1_HUMANligand -> receptorHPMR
EPHB1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
EPHB1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
EPHB1_HUMANEPHB1_HUMANkinase -> substrateHPRD
EPHB1_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANEPHB1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneIEAcellular_component
GO:0060996dendritic spine developmentISSbiological_process
GO:0005003ephrin receptor activityIEAmolecular_function
GO:0070372regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0007411axon guidanceISSbiological_process
GO:0022008neurogenesisISSbiological_process
GO:0050965detection of temperature stimulus involved in sensIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0051965positive regulation of synapse assemblyIEAbiological_process
GO:0021952central nervous system projection neuron axonogeneIEAbiological_process
GO:0021545cranial nerve developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0046328regulation of JNK cascadeIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0008046axon guidance receptor activityIEAmolecular_function
GO:0022008neurogenesisIEAbiological_process
GO:0060326cell chemotaxisIEAbiological_process
GO:0031901early endosome membraneIDAcellular_component
GO:0048593camera-type eye morphogenesisIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0060996dendritic spine developmentIEAbiological_process
GO:0030010establishment of cell polarityIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0060997dendritic spine morphogenesisIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0021631optic nerve morphogenesisIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0045121membrane raftIEAcellular_component
GO:0061351neural precursor cell proliferationIEAbiological_process
GO:0031290retinal ganglion cell axon guidanceIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0001525angiogenesisIDAbiological_process
GO:0048013ephrin receptor signaling pathwayIEAbiological_process
GO:0005005transmembrane-ephrin receptor activityIDAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0031589cell-substrate adhesionIDAbiological_process
GO:0030424axonIEAcellular_component