Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:E2AK1_HUMAN
Description:eukaryotic translation initiation factor 2-alpha kinase 1 [Source:HGNC Symbol;Acc:24921]
Location:chr7 p22.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S274VKNDEsSSSSIPkinasePhosphoSitePlus
S276NDESSsSSIIFHPRD
S275KNDESsSSSIIPkinasePhosphoSitePlus
S6MQGGNsGVRKRPhosphoSitePlus; SysPTM
S6VRKRHPRD; SysPTM
S276NDESSsSSIIFPkinasePhosphoSitePlus
S295KRFGEsDTENQPkinasePhosphoSitePlus; SysPTM
S295KRFGEsDTENQHPRD; SysPTM
S275KNDESsSSSIIHPRD
S258SLEVLsDQEEDHPRD; SysPTM
S258SLEVLsDQEEDPkinasePhosphoSitePlus; SysPTM
S278ESSSSsIIFAEHPRD
Y38GPDPEyDESDVHPRD
S277DESSSsSIIFAHPRD
S274VKNDEsSSSSIHPRD

Dephosphorylation site
E2AK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000199389G202SGreenman2007, HPILung Cancer16140923, 17344846, 18428421

Differential expressed protein
E2AK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
E2AK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
E2AK1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
E2AK1_HUMANIF2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05168Herpes simplex infection
hsa04141Protein processing in endoplasmic reticulum
hsa05164Influenza A
hsa05160Hepatitis C
hsa05169Epstein-Barr virus infection
hsa05162Measles

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046984regulation of hemoglobin biosynthetic processIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0020037heme bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0010999regulation of eIF2 alpha phosphorylation by hemeIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0046501protoporphyrinogen IX metabolic processIEAbiological_process
GO:0020037heme bindingISSmolecular_function
GO:0045993negative regulation of translational initiation byNASbiological_process
GO:0046986negative regulation of hemoglobin biosynthetic proIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0046777protein autophosphorylationISSbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0042803protein homodimerization activityISSmolecular_function
GO:0046986negative regulation of hemoglobin biosynthetic proISSbiological_process
GO:0009605response to external stimulusIEPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0006417regulation of translationIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0004694eukaryotic translation initiation factor 2alpha kiIDAmolecular_function
GO:0006950response to stressIEPbiological_process


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