| UniProt/SwissProt ID: | E2AK1_HUMAN |
| Description: | eukaryotic translation initiation factor 2-alpha kinase 1 [Source:HGNC Symbol;Acc:24921] |
| Location: | chr7 p22.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S274 | VKNDEsSSSSI | Pkinase | PhosphoSitePlus |
| S276 | NDESSsSSIIF | HPRD | |
| S275 | KNDESsSSSII | Pkinase | PhosphoSitePlus |
| S6 | MQGGNsGVRKR | PhosphoSitePlus; SysPTM | |
| S6 | VRKR | HPRD; SysPTM | |
| S276 | NDESSsSSIIF | Pkinase | PhosphoSitePlus |
| S295 | KRFGEsDTENQ | Pkinase | PhosphoSitePlus; SysPTM |
| S295 | KRFGEsDTENQ | HPRD; SysPTM | |
| S275 | KNDESsSSSII | HPRD | |
| S258 | SLEVLsDQEED | HPRD; SysPTM | |
| S258 | SLEVLsDQEED | Pkinase | PhosphoSitePlus; SysPTM |
| S278 | ESSSSsIIFAE | HPRD | |
| Y38 | GPDPEyDESDV | HPRD | |
| S277 | DESSSsSIIFA | HPRD | |
| S274 | VKNDEsSSSSI | HPRD | |
| Dephosphorylation site |
| E2AK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000199389 | G202S | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 |
| Differential expressed protein |
| E2AK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| E2AK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| E2AK1_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| E2AK1_HUMAN | IF2A_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05168 | Herpes simplex infection |
| hsa04141 | Protein processing in endoplasmic reticulum |
| hsa05164 | Influenza A |
| hsa05160 | Hepatitis C |
| hsa05169 | Epstein-Barr virus infection |
| hsa05162 | Measles |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046984 | regulation of hemoglobin biosynthetic process | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0020037 | heme binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0010999 | regulation of eIF2 alpha phosphorylation by heme | IEA | biological_process |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0046501 | protoporphyrinogen IX metabolic process | IEA | biological_process |
| GO:0020037 | heme binding | ISS | molecular_function |
| GO:0045993 | negative regulation of translational initiation by | NAS | biological_process |
| GO:0046986 | negative regulation of hemoglobin biosynthetic pro | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0046777 | protein autophosphorylation | ISS | biological_process |
| GO:0008285 | negative regulation of cell proliferation | IEA | biological_process |
| GO:0042803 | protein homodimerization activity | ISS | molecular_function |
| GO:0046986 | negative regulation of hemoglobin biosynthetic pro | ISS | biological_process |
| GO:0009605 | response to external stimulus | IEP | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0006417 | regulation of translation | IEA | biological_process |
| GO:0046777 | protein autophosphorylation | IEA | biological_process |
| GO:0004694 | eukaryotic translation initiation factor 2alpha ki | IDA | molecular_function |
| GO:0006950 | response to stress | IEP | biological_process |