| UniProt/SwissProt ID: | ANPRB_HUMAN |
| Description: | natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) [Source:HGNC Symbol;Acc:7944] |
| Location: | chr9 p13.3 |
| Node attribute: | receptor; kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T516 | AGSRLtLSLRG | PhosphoSitePlus; HPRD | |
| Y747 | NGQRPyFRPSI | Pkinase_Tyr | PhosphoSitePlus |
| T820 | LVEERtQAYLE | HNOBA | PhosphoSitePlus |
| S526 | GSSYGsLMTAH | PhosphoSitePlus; HPRD | |
| S518 | SRLTLsLRGSS | PhosphoSitePlus; HPRD | |
| S523 | SLRGSsYGSLM | PhosphoSitePlus; HPRD | |
| S513 | HKGAGsRLTLS | PhosphoSitePlus; HPRD | |
| T529 | YGSLMtAHGKY | PhosphoSitePlus | |
| S489 | EKELAsMLWRI | PhosphoSitePlus | |
| Dephosphorylation site |
| ANPRB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000341083 | V960F | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000341083 | breast ductal carcinoma | Normal vs. Cancer | tissue | Down | 18564057 | |
| Hyperphosphorylation site |
| ANPRB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ANFC_HUMAN | ANPRB_HUMAN | ligand -> receptor | HPMR |
| ANFB_HUMAN | ANPRB_HUMAN | ligand -> receptor | HPMR |
| ANPRB_HUMAN | KCIP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | TIPIN_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | TRI36_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | RAB5C_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | TRI26_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | GCFC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | C2D1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | UB2V1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | ACOC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | S10AB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | SMAD4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | NUDT4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | F110A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | UBTD2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | PSA6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | MDM2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | EGFR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | PSA7L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | RMP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | ZCHC2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | CSDC2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | SRXN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | P5CR1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | DGCR8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | SYCP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04270 | Vascular smooth muscle contraction |
| hsa00230 | Purine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0004383 | guanylate cyclase activity | IEA | molecular_function |
| GO:0016849 | phosphorus-oxygen lyase activity | IEA | molecular_function |
| GO:0016941 | natriuretic peptide receptor activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0001503 | ossification | IEA | biological_process |
| GO:0042562 | hormone binding | IPI | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0008217 | regulation of blood pressure | TAS | biological_process |
| GO:0004383 | guanylate cyclase activity | IDA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016941 | natriuretic peptide receptor activity | IDA | molecular_function |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0017046 | peptide hormone binding | IEA | molecular_function |
| GO:0007168 | receptor guanylyl cyclase signaling pathway | IDA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0097011 | cellular response to granulocyte macrophage colony | IEP | biological_process |
| GO:0006182 | cGMP biosynthetic process | IEA | biological_process |
| GO:0060348 | bone development | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0006182 | cGMP biosynthetic process | IDA | biological_process |
| GO:0009190 | cyclic nucleotide biosynthetic process | IEA | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0042802 | identical protein binding | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004872 | receptor activity | TAS | molecular_function |