Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANPRB_HUMAN
Description:natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) [Source:HGNC Symbol;Acc:7944]
Location:chr9 p13.3
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T516AGSRLtLSLRGPhosphoSitePlus; HPRD
Y747NGQRPyFRPSIPkinase_TyrPhosphoSitePlus
T820LVEERtQAYLEHNOBAPhosphoSitePlus
S526GSSYGsLMTAHPhosphoSitePlus; HPRD
S518SRLTLsLRGSSPhosphoSitePlus; HPRD
S523SLRGSsYGSLMPhosphoSitePlus; HPRD
S513HKGAGsRLTLSPhosphoSitePlus; HPRD
T529YGSLMtAHGKYPhosphoSitePlus
S489EKELAsMLWRIPhosphoSitePlus

Dephosphorylation site
ANPRB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000341083V960FTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000341083breast ductal carcinomaNormal vs. CancertissueDown18564057

Hyperphosphorylation site
ANPRB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANFC_HUMANANPRB_HUMANligand -> receptorHPMR
ANFB_HUMANANPRB_HUMANligand -> receptorHPMR
ANPRB_HUMANKCIP2_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANTIPIN_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANTRI36_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANRAB5C_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANTRI26_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANC2D1A_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANUB2V1_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANACOC_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANNUDT4_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANF110A_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANUBTD2_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANEGFR_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANPSA7L_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANRMP_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANZCHC2_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANP5CR1_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANDGCR8_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANSYCP2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04270Vascular smooth muscle contraction
hsa00230Purine metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005525GTP bindingIEAmolecular_function
GO:0004383guanylate cyclase activityIEAmolecular_function
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0016941natriuretic peptide receptor activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0001503ossificationIEAbiological_process
GO:0042562hormone bindingIPImolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0008217regulation of blood pressureTASbiological_process
GO:0004383guanylate cyclase activityIDAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0016941natriuretic peptide receptor activityIDAmolecular_function
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0017046peptide hormone bindingIEAmolecular_function
GO:0007168receptor guanylyl cyclase signaling pathwayIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0007165signal transductionNASbiological_process
GO:0097011cellular response to granulocyte macrophage colonyIEPbiological_process
GO:0006182cGMP biosynthetic processIEAbiological_process
GO:0060348bone developmentIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0006182cGMP biosynthetic processIDAbiological_process
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0004872receptor activityTASmolecular_function


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