Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SCYL2_HUMAN
Description:SCY1-like 2 (S. cerevisiae) [Source:HGNC Symbol;Acc:19286]
Location:chr12 q23.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T737SLSVStPKSSAPhosphoSitePlus
S277QDIYKsFSRQLPkinasePhosphoSitePlus
Y795TNQNFySSPSTPhosphoSitePlus
T440LLLTKtPPDEIPhosphoSitePlus; HPRD; phosphoELM
S677KHKRAsLTLEEHPRD; phosphoELM; SysPTM
S350DNLQKsQFFKGPhosphoSitePlus
Y275NKQDIyKSFSRPkinasePhosphoSitePlus
S677KHKRAsLTLEECENP-B_NPhosphoSitePlus; SysPTM
T760GMMFStPTDNTPhosphoSitePlus
T438MDLLLtKTPPDPhosphoSitePlus; HPRD; phosphoELM
S759IGMMFsTPTDNPhosphoSitePlus

Dephosphorylation site
SCYL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354061G355RTCGAOvarian Cancer21720365, 18772890
ENSP00000354061Q863HHPILung Cancer17344846
ENSP00000354061R505HTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
SCYL2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SCYL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SCYL2_HUMANF110A_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANKPYM_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANRMP_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMAN1433E_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANGELS_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANCDA7L_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANG3P_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANCLIC1_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANUBTD2_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANHS71L_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANNCALD_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANRAB5C_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANANXA2_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SCYL2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:2000286receptor internalization involved in canonical WntIDAbiological_process
GO:0008333endosome to lysosome transportIDAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005488bindingIEAmolecular_function
GO:0002092positive regulation of receptor internalizationIDAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0030136clathrin-coated vesicleIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIDAbiological_process
GO:2000370positive regulation of clathrin-mediated endocytosIDAbiological_process
GO:0010008endosome membraneIEAcellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function


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