| UniProt/SwissProt ID: | SCYL2_HUMAN |
| Description: | SCY1-like 2 (S. cerevisiae) [Source:HGNC Symbol;Acc:19286] |
| Location: | chr12 q23.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T737 | SLSVStPKSSA | PhosphoSitePlus | |
| S277 | QDIYKsFSRQL | Pkinase | PhosphoSitePlus |
| Y795 | TNQNFySSPST | PhosphoSitePlus | |
| T440 | LLLTKtPPDEI | PhosphoSitePlus; HPRD; phosphoELM | |
| S677 | KHKRAsLTLEE | HPRD; phosphoELM; SysPTM | |
| S350 | DNLQKsQFFKG | PhosphoSitePlus | |
| Y275 | NKQDIyKSFSR | Pkinase | PhosphoSitePlus |
| S677 | KHKRAsLTLEE | CENP-B_N | PhosphoSitePlus; SysPTM |
| T760 | GMMFStPTDNT | PhosphoSitePlus | |
| T438 | MDLLLtKTPPD | PhosphoSitePlus; HPRD; phosphoELM | |
| S759 | IGMMFsTPTDN | PhosphoSitePlus | |
| Dephosphorylation site |
| SCYL2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000354061 | G355R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000354061 | Q863H | HPI | Lung Cancer | 17344846 | ENSP00000354061 | R505H | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| SCYL2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SCYL2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SCYL2_HUMAN | F110A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | KPYM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | RMP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | 1433E_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | MK01_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | FGR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | HNRPK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | GELS_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | CDA7L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | G3P_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | CLIC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | UBTD2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | UBB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | IF4B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | MDM2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | HS71L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | 1433F_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | NCALD_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | RAB5C_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | GCFC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | ANXA2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | SRC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SCYL2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:2000286 | receptor internalization involved in canonical Wnt | IDA | biological_process |
| GO:0008333 | endosome to lysosome transport | IDA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005102 | receptor binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0002092 | positive regulation of receptor internalization | IDA | biological_process |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0030136 | clathrin-coated vesicle | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0090090 | negative regulation of canonical Wnt receptor sign | IDA | biological_process |
| GO:2000370 | positive regulation of clathrin-mediated endocytos | IDA | biological_process |
| GO:0010008 | endosome membrane | IEA | cellular_component |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |