Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MAPK3_HUMAN
Description:mitogen-activated protein kinase-activated protein kinase 3 [Source:HGNC Symbol;Acc:6888]
Location:chr3 p21.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y207PCYTPyYVAPEHPRD
T317QTPLHtARVLQPhosphoSitePlus
S244FPPFYsNTGQAHPRD
S376GSSSAsQGCNNPhosphoSitePlus
Y208CYTPYyVAPEVHPRD
S372KKQAGsSSASQPhosphoSitePlus
Y76ALKLLyDSPKAPkinase_CAMKPhosphoSitePlus
Y204LQTPCyTPYYVHPRD
Y204LQTPCyTPYYVPkinase_CAMKPhosphoSitePlus
S374QAGSSsASQGCPhosphoSitePlus
T201QNALQtPCYTPPkinase_CAMKPhosphoSitePlus
S373KQAGSsSASQGPhosphoSitePlus
S251TGQAIsPGMKRPkinase_CAMKPhosphoSitePlus
Y208CYTPYyVAPEVPkinase_CAMKPhosphoSitePlus
S251TGQAIsPGMKRHPRD
T313MVVPQtPLHTAPhosphoSitePlus
T246PFYSNtGQAISHPRD
T205QTPCYtPYYVAPkinase_CAMKPhosphoSitePlus
T246PFYSNtGQAISPkinase_CAMKPhosphoSitePlus
S307PWINQsMVVPQPhosphoSitePlus
T5_MDGEtAEEQGPhosphoSitePlus
S244FPPFYsNTGQAPkinase_CAMKPhosphoSitePlus
Y346TMRVDyDQVKIPhosphoSitePlus
Y43AVTDDyQLSKQPkinase_CAMKPhosphoSitePlus
Y207PCYTPyYVAPEPkinase_CAMKPhosphoSitePlus

Dephosphorylation site
MAPK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000396467K255NCOSMICHepatocellular Carcinoma21822264
ENSP00000396467P28SHPINeoplasms by Histologic Type17344846
ENSP00000350639P28SGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000396467S337TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000396467V39GCOSMICOvarian Cancer21720365
ENSP00000350639P28SGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000350639E105AGreenman2007Ovarian Cancer17344846, 18428421
ENSP00000350639S337TBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
MAPK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MAPK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MAPK3_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK3_HUMANCPZIP_HUMANkinase -> substrateRegPhos
ST17A_HUMANMAPK3_HUMANkinase -> substrateRobert H Newman (2013)
MAPK3_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
MAPK3_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
MAPK3_HUMANHSPB1_HUMANkinase -> substrateRegPhos
MAPK3_HUMANMYF6_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANMAPK3_HUMANkinase -> substrateKEGG
MAPK3_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK3_HUMANATF4_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04370VEGF signaling pathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0007265Ras protein signal transductionTASbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0005634nucleusTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0006950response to stressIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0002224toll-like receptor signaling pathwayIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0004708MAP kinase kinase activityTASmolecular_function
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0044351macropinocytosisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process