Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STK3_HUMAN
Description:serine/threonine kinase 3 [Source:HGNC Symbol;Acc:11406]
Location:chr8 q22.2
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y81QCDSPyVVKYYPkinasePhosphoSitePlus
T240TNPPPtFRKPEPkinasePhosphoSitePlus
Y396PSFMDyFDKQDPhosphoSitePlus
S444FLKNLsLEELQHPRD
S18KLSEDsLTKQPPhosphoSitePlus
T180MAKRNtVIGTPautocatalysis RegPhos
T180MAKRNtVIGTPPkinasePhosphoSitePlus
S333KTSVEsVGTMRPhosphoSitePlus
T325ELDSHtMVKTSPhosphoSitePlus; HPRD
T174GQLTDtMAKRNPkinasePhosphoSitePlus
T336VESVGtMRATSPhosphoSitePlus
S316EEEENsDEDELPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T180MAKRNtVIGTPMST2RegPhos
T180MAKRNtVIGTPphosphoELM; RegPhos
S15KLKKLsEDSLTPhosphoSitePlus; HPRD
T180MAKRNtVIGTPSTK3HPRD
T235IFMIPtNPPPTPkinasePhosphoSitePlus
S392QVQRPsFMDYFPhosphoSitePlus
S385KRNATsPQVQRPhosphoSitePlus; HPRD
T117RLRNKtLIEDEPkinasePhosphoSitePlus
T384MKRNAtSPQVQPhosphoSitePlus; HPRD; phosphoELM
S444FLKNLsLEELQMst1_SARAHPhosphoSitePlus
S323EDELDsHTMVKPhosphoSitePlus

Dephosphorylation site
STK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000390500V60LHPIOvarian Cancer17344846

Differential expressed protein
STK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T117PkinaseIIRLRNKtLIEDEIAbreast cancer20231902PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
STK3_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANSTK3_HUMANkinase -> substrateRegPhos
STK3_HUMANWWTR1_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANSTK3_HUMANkinase -> substrateHPRD; RegPhos
STK3_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANUBL4B_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANLATS1_HUMANkinase -> substrateRegPhos
STK3_HUMANKPYM_HUMANkinase -> substrateRobert H Newman (2013)
STK3_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
CASP3_HUMANSTK3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006915apoptotic processTASbiological_process
GO:0046330positive regulation of JNK cascadeIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0003157endocardium developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0060706cell differentiation involved in embryonic placentIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046621negative regulation of organ growthIEAbiological_process
GO:0071902positive regulation of protein serine/threonine kiIDAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0046983protein dimerization activityISSmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0043065positive regulation of apoptotic processISSbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0035329hippo signaling cascadeTASbiological_process
GO:0060215primitive hemopoiesisIEAbiological_process
GO:0043539protein serine/threonine kinase activator activityIDAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:0001841neural tube formationIEAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23