Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYO3A_HUMAN
Description:myosin IIIA [Source:HGNC Symbol;Acc:7601]
Location:chr10 p12.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y85RFYGIyFKKDKPkinasePhosphoSitePlus
S1280AENETsFKKTLPhosphoSitePlus
S1167SVVKTsTFKPEPhosphoSitePlus
Y1125DQEFDyKKNFEPhosphoSitePlus
S1355AVFIQsKYRGYIQPhosphoSitePlus
Y1396HNLYSyPTKHEPhosphoSitePlus
T1279LAENEtSFKKTPhosphoSitePlus
S688YGRLFsWIVNCMyosin_headPhosphoSitePlus
Y1394NTHNLySYPTKPhosphoSitePlus
Y82NVVRFyGIYFKPkinasePhosphoSitePlus
Y509AQISEyLLEKSHPRD
Y509AQISEyLLEKSMyosin_headPhosphoSitePlus
T178AQLTStRHRRNPkinasePhosphoSitePlus
T853RDTLPtDIVLLMyosin_headPhosphoSitePlus
S1355AVFIQsKYRGYHPRD; phosphoELM
Y1459QLKSLyLGVSHPhosphoSitePlus

Dephosphorylation site
MYO3A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265944P1287HTCGAOvarian Cancer21720365, 18772890
ENSP00000265944N525HTCGAOvarian Cancer21720365, 18772890
ENSP00000265944Q447HDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000265944A833PBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000265944D271ETCGAOvarian Cancer21720365, 18772890
ENSP00000265944S956RGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000265944D1347HGreenman2007, HPIRenal Cancer17344846, 18428421
ENSP00000265944Q1079LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000265944R1358LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265944A904SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000265944H1400YTCGAOvarian Cancer21720365, 18772890
ENSP00000265944L394ITCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000265944T1284SBIOMARTGastric Cancer21930507, 21930502
ENSP00000265944N525KGreenman2007, HPIOvarian Cancer17344846, 18428421

Differential expressed protein
MYO3A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MYO3A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MYO3A_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
MYO3A_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
MYO3A_HUMANSQSTM_HUMANkinase -> substrateRobert H Newman (2013)
MYO3A_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MYO3A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031941filamentous actinIDAcellular_component
GO:0007605sensory perception of soundIMPbiological_process
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0003774motor activityIEAmolecular_function
GO:0030175filopodiumIDAcellular_component
GO:0007605sensory perception of soundIEAbiological_process
GO:0000146microfilament motor activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0001917photoreceptor inner segmentIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0032426stereocilium bundle tipIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0051491positive regulation of filopodium assemblyIEAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0000146microfilament motor activityIDAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0043531ADP bindingIDAmolecular_function
GO:0030898actin-dependent ATPase activityIDAmolecular_function
GO:0050896response to stimulusIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0016459myosin complexIEAcellular_component
GO:0007601visual perceptionIEAbiological_process
GO:0032433filopodium tipIEAcellular_component
GO:0060002plus-end directed microfilament motor activityIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005516calmodulin bindingIDAmolecular_function
GO:0051015actin filament bindingIEAmolecular_function


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