| UniProt/SwissProt ID: | MYO3A_HUMAN |
| Description: | myosin IIIA [Source:HGNC Symbol;Acc:7601] |
| Location: | chr10 p12.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y85 | RFYGIyFKKDK | Pkinase | PhosphoSitePlus |
| S1280 | AENETsFKKTL | PhosphoSitePlus | |
| S1167 | SVVKTsTFKPE | PhosphoSitePlus | |
| Y1125 | DQEFDyKKNFE | PhosphoSitePlus | |
| S1355 | AVFIQsKYRGY | IQ | PhosphoSitePlus |
| Y1396 | HNLYSyPTKHE | PhosphoSitePlus | |
| T1279 | LAENEtSFKKT | PhosphoSitePlus | |
| S688 | YGRLFsWIVNC | Myosin_head | PhosphoSitePlus |
| Y1394 | NTHNLySYPTK | PhosphoSitePlus | |
| Y82 | NVVRFyGIYFK | Pkinase | PhosphoSitePlus |
| Y509 | AQISEyLLEKS | HPRD | |
| Y509 | AQISEyLLEKS | Myosin_head | PhosphoSitePlus |
| T178 | AQLTStRHRRN | Pkinase | PhosphoSitePlus |
| T853 | RDTLPtDIVLL | Myosin_head | PhosphoSitePlus |
| S1355 | AVFIQsKYRGY | HPRD; phosphoELM | |
| Y1459 | QLKSLyLGVSH | PhosphoSitePlus | |
| Dephosphorylation site |
| MYO3A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265944 | P1287H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000265944 | N525H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000265944 | Q447H | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000265944 | A833P | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000265944 | D271E | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000265944 | S956R | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 | ENSP00000265944 | D1347H | Greenman2007, HPI | Renal Cancer | 17344846, 18428421 | ENSP00000265944 | Q1079L | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000265944 | R1358L | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000265944 | A904S | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000265944 | H1400Y | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000265944 | L394I | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000265944 | T1284S | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000265944 | N525K | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 |
| Differential expressed protein |
| MYO3A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MYO3A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MYO3A_HUMAN | UHMK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MYO3A_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MYO3A_HUMAN | SQSTM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MYO3A_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MYO3A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031941 | filamentous actin | IDA | cellular_component |
| GO:0007605 | sensory perception of sound | IMP | biological_process |
| GO:0018105 | peptidyl-serine phosphorylation | IEA | biological_process |
| GO:0003774 | motor activity | IEA | molecular_function |
| GO:0030175 | filopodium | IDA | cellular_component |
| GO:0007605 | sensory perception of sound | IEA | biological_process |
| GO:0000146 | microfilament motor activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0001917 | photoreceptor inner segment | IEA | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0032426 | stereocilium bundle tip | IEA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0018107 | peptidyl-threonine phosphorylation | IEA | biological_process |
| GO:0048839 | inner ear development | IEA | biological_process |
| GO:0051491 | positive regulation of filopodium assembly | IEA | biological_process |
| GO:0004672 | protein kinase activity | IDA | molecular_function |
| GO:0000146 | microfilament motor activity | IDA | molecular_function |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0046777 | protein autophosphorylation | IEA | biological_process |
| GO:0043531 | ADP binding | IDA | molecular_function |
| GO:0030898 | actin-dependent ATPase activity | IDA | molecular_function |
| GO:0050896 | response to stimulus | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016459 | myosin complex | IEA | cellular_component |
| GO:0007601 | visual perception | IEA | biological_process |
| GO:0032433 | filopodium tip | IEA | cellular_component |
| GO:0060002 | plus-end directed microfilament motor activity | IDA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005516 | calmodulin binding | IDA | molecular_function |
| GO:0051015 | actin filament binding | IEA | molecular_function |