Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CREB1_HUMAN
Description:cAMP responsive element binding protein 1 [Source:HGNC Symbol;Acc:2345]
Location:chr2 q33.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S133LSRRPsYRKILRSK-3phosphoELM
S129RREILsRRPSYGSK3BHPRD; RegPhos
S143LNDLSsDAPGVpKIDPhosphoSitePlus
S156IEEEKsEEETSPhosphoSitePlus
S142ILNDLsSDAPGHPRD
S133LSRRPsYRKILRPS6KA5HPRD
S133LSRRPsYRKILpKIDPhosphoSitePlus
S133LSRRPsYRKILCaMK4RegPhos
S111AESEDsQESVDATMHPRD; phosphoELM; RegPhos
S133LSRRPsYRKILRPS6KA4HPRD
S133LSRRPsYRKILRPS6KA2HPRD
S133LSRRPsYRKILRPS6KA1HPRD
T100RLFSGtQISTIPhosphoSitePlus
S133LSRRPsYRKILPKG1RegPhos
S129RREILsRRPSYGSK_groupRegPhos
T100RLFSGtQISTIATMHPRD
S133LSRRPsYRKILCaM-KIVphosphoELM
S111AESEDsQESVDPhosphoSitePlus; phosphoELM; RegPhos
S115RREILsRRPSYGSK3BHPRD
S133LSRRPsYRKILPRKG1HPRD
S133LSRRPsYRKILp38a(MAPK14RegPhos
S133LSRRPsYRKILRSK3RegPhos
S133LSRRPsYRKILHPRD; phosphoELM; RegPhos
S142ILNDLsSDAPGCaMK2_group RegPhos
S133LSRRPsYRKILPKA_groupRegPhos
S121DSVTDsQKRREATMHPRD; phosphoELM; RegPhos
S119LSRRPsYRKILHPRD
S142ILNDLsSDAPGCaM-KII_groupphosphoELM
S133LSRRPsYRKILRPS6KA3HPRD
T119SVDSVtDSQKRpKIDPhosphoSitePlus
S133LSRRPsYRKILMAPKAPK2HPRD; phosphoELM; RegPhos
S117QESVDsVTDSQpKIDPhosphoSitePlus
S133LSRRPsYRKILCaMK2_groupRegPhos
S142ILNDLsSDAPGCaMK2_groupRegPhos
S97AESEDsQESVDATMHPRD
S133LSRRPsYRKILDYRK3phosphoELM
S133LSRRPsYRKILAKT_groupRegPhos
S108STIAEsEDSQEPhosphoSitePlus
S133LSRRPsYRKILCaM-KII_groupphosphoELM
S107DSVTDsQKRREATMHPRD
S133LSRRPsYRKILSGK1HPRD; RegPhos
S121DSVTDsQKRREpKIDPhosphoSitePlus
T119SVDSVtDSQKRHPRD; phosphoELM; RegPhos
S98LKRLFsGTQISPhosphoSitePlus
S133LSRRPsYRKILTSSK4HPRD
S271VVMASsPALPTPhosphoSitePlus
S133LSRRPsYRKILCaMK1aRegPhos
S133LSRRPsYRKILSGK_groupphosphoELM; RegPhos
S270GVVMAsSPALPHPRD; phosphoELM
S142ILNDLsSDAPGpKIDPhosphoSitePlus
S121DSVTDsQKRREATRphosphoELM; RegPhos
S133LSRRPsYRKILRSK_groupphosphoELM; RegPhos
S133LSRRPsYRKILRSK-2phosphoELM
S133LSRRPsYRKILRSK2RegPhos
S133LSRRPsYRKILAKT1HPRD; RegPhos
S119LSRRPsYRKILSGK1HPRD
S256GVVMAsSPALPHPRD
S133LSRRPsYRKILDYRKRegPhos
S129RREILsRRPSYGSK-3_groupphosphoELM
S114EDSQEsVDSVTpKIDPhosphoSitePlus
S133LSRRPsYRKILMSK1RegPhos
S129RREILsRRPSYpKIDPhosphoSitePlus
S133LSRRPsYRKILRSK1RegPhos
Y134SRRPSyRKILNpKIDPhosphoSitePlus
S128ILNDLsSDAPGHPRD
S133LSRRPsYRKILMSK2RegPhos

Dephosphorylation site
CREB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000387699E109KBIOMARTBreast Cancer21930507, 21930502
ENSP00000236995E95KBIOMARTBreast Cancer21930507, 21930502
ENSP00000363518E109KBIOMARTBreast Cancer21930507, 21930502
ENSP00000405539E95KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CREB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S129pKIDQKRREILsRRPSYRKprostate cancer12900420PhosphoSitePlus
S133pKIDEILSRRPsYRKILNDprostate cancer12900420PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos
AKT1_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos
KS6A2_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
TSSK4_HUMANCREB1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANCREB1_HUMANkinase -> substrateRegPhos
MAPK2_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos; NetPath
KS6A3_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KGP1_HUMANCREB1_HUMANkinase -> substrateHPRD
DYRK3_HUMANCREB1_HUMANkinase -> substrateRobert H Newman (2013)
SGK1_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos
ATM_HUMANCREB1_HUMANkinase -> substrateRegPhos
ATR_HUMANCREB1_HUMANkinase -> substrateRegPhos
KCC4_HUMANCREB1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANCREB1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos
KS6A1_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos; NetPath
DYR1A_HUMANCREB1_HUMANkinase -> substrateRegPhos
MARK2_HUMANCREB1_HUMANkinase -> substrateRobert H Newman (2013)
CREB1_HUMANDOPO_HUMANTF -> target geneTRANSFAC
CREB1_HUMANGLHA_HUMANTF -> target geneTRANSFAC
CREB1_HUMANTPA_HUMANTF -> target geneTRANSFAC
CREB1_HUMANPSN1_HUMANTF -> target geneTRANSFAC
CREB1_HUMANCCNA2_HUMANTF -> target geneTRANSFAC
CREB1_HUMANVIP_HUMANTF -> target geneTRANSFAC
CREB1_HUMANCCL5_HUMANTF -> target geneTRANSFAC
CREB1_HUMANU627C_HUMANTF -> target geneTRANSFAC
CREB1_HUMANEGR1_HUMANTF -> target geneTRANSFAC
CREB1_HUMANFINC_HUMANTF -> target geneTRANSFAC
CREB1_HUMANMPCP_HUMANTF -> target geneTRANSFAC
CREB1_HUMANLORI_HUMANTF -> target geneTRANSFAC
CREB1_HUMANCRF_HUMANTF -> target geneTRANSFAC
CREB1_HUMANINS_HUMANTF -> target geneTRANSFAC
CREB1_HUMANMITF_HUMANTF -> target geneTRANSFAC
CREB1_HUMANRL10_HUMANTF -> target geneTRANSFAC
CREB1_HUMANTRH_HUMANTF -> target geneTRANSFAC
CREB1_HUMANADRB2_HUMANTF -> target geneTRANSFAC
CREB1_HUMANDPB1_HUMANTF -> target geneTRANSFAC
CREB1_HUMANIBP1_HUMANTF -> target geneTRANSFAC
CREB1_HUMANDRB4_HUMANTF -> target geneTRANSFAC
CREB1_HUMANFOS_HUMANTF -> target geneTRANSFAC
CREB1_HUMANBDNF_HUMANTF -> target geneTRANSFAC
CREB1_HUMANCFTR_HUMANTF -> target geneTRANSFAC
CREB1_HUMANDRA_HUMANTF -> target geneTRANSFAC
CREB1_HUMANCCND1_HUMANTF -> target geneTRANSFAC
CREB1_HUMANPTHY_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05215Prostate cancer
hsa05166HTLV-I infection
hsa04962Vasopressin-regulated water reabsorption
hsa05016Huntington's disease
hsa04728Dopaminergic synapse
hsa04725Cholinergic synapse
hsa05152Tuberculosis
hsa04612Antigen processing and presentation
hsa04916Melanogenesis
hsa05203Viral carcinogenesis
hsa05034Alcoholism
hsa04380Osteoclast differentiation
hsa05031Amphetamine addiction
hsa05030Cocaine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001190RNA polymerase II transcription factor binding traIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0000980RNA polymerase II distal enhancer sequence-specifiIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0046887positive regulation of hormone secretionIEAbiological_process
GO:0007595lactationIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIDAmolecular_function
GO:0003712transcription cofactor activityTASmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0001102RNA polymerase II activating transcription factor IPImolecular_function
GO:0010033response to organic substanceIDAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0035497cAMP response element bindingIDAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0000790nuclear chromatinIEAcellular_component
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0010944negative regulation of transcription by competitivIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0021983pituitary gland developmentIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0008361regulation of cell sizeIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0046889positive regulation of lipid biosynthetic processIEAbiological_process
GO:0050821protein stabilizationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0045600positive regulation of fat cell differentiationIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0005719nuclear euchromatinIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process