Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CRK_HUMAN
Description:v-crk sarcoma virus CT10 oncogene homolog (avian) [Source:HGNC Symbol;Acc:2362]
Location:chr17 p13.3
Node attribute:PPI(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y136QEEAEyVRALFPhosphoSitePlus
S85PGVSPsRLRIGSH2PhosphoSitePlus
Y221PEPGPyAQPSVAblphosphoELM
S125RSRQGsGVILRPhosphoSitePlus; HPRD
T113YLDTTtLIEPVPhosphoSitePlus
T42VRDSStSPGDYSH2PhosphoSitePlus
T112HYLDTtTLIEPPhosphoSitePlus
S74PPVPPsPAQPPHPRD; phosphoELM
Y108FYKIHyLDTTTPhosphoSitePlus
S83PPPGVsPSRLRSH2PhosphoSitePlus
Y190PYVEKyRPASAPhosphoSitePlus
Y221PEPGPyAQPSVPhosphoSitePlus; phosphoELM; RegPhos
Y221PEPGPyAQPSVEGFRHPRD; RegPhos
S198ASASVsALIGGPhosphoSitePlus
S43RDSSTsPGDYVSH2PhosphoSitePlus
S83PPPGVsPSRLRHPRD; phosphoELM
Y221PEPGPyAQPSVIGF1RHPRD; RegPhos
S96DQEFDsLPALLSH2PhosphoSitePlus
S74PPVPPsPAQPPSH2PhosphoSitePlus
S304PDEDHPRD
S225PYAQPsVNTPLPhosphoSitePlus
Y239QNGPIyARVIQHPRD; RegPhos
Y239QNGPIyARVIQSH3_2PhosphoSitePlus
S85PGVSPsRLRIGHPRD
T42VRDSStSPGDYHPRD; RegPhos
S208GNQEGsHPQPLPhosphoSitePlus
T228QPSVNtPLPNLPhosphoSitePlus
S40FLVRDsSTSPGHPRD
S194KYRPAsASVSAPhosphoSitePlus; HPRD
S41LVRDSsTSPGDHPRD; RegPhos
S40FLVRDsSTSPGSH2PhosphoSitePlus
Y47TSPGDyVLSVSSH2PhosphoSitePlus
Y251RVPNAyDKTALSH3_2PhosphoSitePlus
S41LVRDSsTSPGDSH2PhosphoSitePlus
S196RPASAsVSALIPhosphoSitePlus; HPRD
T254NAYDKtALALESH3_2PhosphoSitePlus
Y221PEPGPyAQPSVABL1HPRD; RegPhos
Y221PEPGPyAQPSVABL2HPRD; RegPhos

Dephosphorylation site
CRK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000300574I161FCOSMICLung Cancer20668451
ENSP00000300574I161FCOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000300574Gastric CancerTreatment (none v.s 100 umol/l of L-homocysteine thiolactone treated)cell lineUp17116298
ENSP00000300574Breast CancerMetastasiscell lineUp1.418582095

Hyperphosphorylation site
CRK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LIMK2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
EPHB3_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
SIK1_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
CDK16_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
EGFR_HUMANCRK_HUMANkinase -> substrateKEGG; HPRD; RegPhos
NIM1_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
NEK3_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
ABL1_HUMANCRK_HUMANkinase -> substrateHPRD; RegPhos
CRK_HUMANFAK1_HUMANkinase -> substrateHPRD
NEK2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANCRK_HUMANkinase -> substrateRegPhos
IGF1R_HUMANCRK_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ABL2_HUMANCRK_HUMANkinase -> substrateHPRD; RegPhos
STK33_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
RIPK2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
BCAR1_HUMANCRK_HUMANotherKEGG
CRK_HUMANABL1_HUMANotherKEGG
CRK_HUMANRHOQ_HUMANotherKEGG
CRK_HUMANRPGF1_HUMANotherKEGG
CRK_HUMANDOCK1_HUMANotherKEGG
CRK_HUMANPAXI_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa04012ErbB signaling pathway
hsa05211Renal cell carcinoma
hsa05200Pathways in cancer
hsa05131Shigellosis
hsa04666Fc gamma R-mediated phagocytosis
hsa05100Bacterial invasion of epithelial cells
hsa04910Insulin signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04510Focal adhesion
hsa04010MAPK signaling pathway
hsa05220Chronic myeloid leukemia
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030674protein binding, bridgingIEAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0046875ephrin receptor bindingIPImolecular_function
GO:0042169SH2 domain bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000186activation of MAPKK activityTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0045309protein phosphorylated amino acid bindingIEAmolecular_function
GO:0035020regulation of Rac protein signal transductionIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005768endosomeTAScellular_component
GO:0048013ephrin receptor signaling pathwayIDAbiological_process
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0005070SH3/SH2 adaptor activityIEAmolecular_function
GO:0032319regulation of Rho GTPase activityIDAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0032956regulation of actin cytoskeleton organizationIDAbiological_process
GO:0005737cytoplasmICcellular_component
GO:0005634nucleusTAScellular_component
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process