| UniProt/SwissProt ID: | ZN823_HUMAN |
| Description: | zinc finger protein 823 [Source:HGNC Symbol;Acc:30936] |
| Location: | chr19 p13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T269 | LRHERtHTGEK | zf-C2H2 | PhosphoSitePlus |
| Y485 | FSCFKyLSQHK | zf-C2H2; C1_4 | PhosphoSitePlus |
| T213 | HLHERtHTGEK | zf-C2H2 | PhosphoSitePlus |
| T215 | HERTHtGEKPY | PhosphoSitePlus | |
| S374 | LSHSSsFRSHM | zf-C2H2 | PhosphoSitePlus |
| T411 | HERTHtGEKPY | C1_4 | PhosphoSitePlus |
| Y260 | KAFPDySTYLR | zf-C2H2 | PhosphoSitePlus |
| T409 | QRHERtHTGEK | zf-C2H2; C1_4 | PhosphoSitePlus |
| T550 | HERIHtGEKPY | PhosphoSitePlus | |
| T271 | HERTHtGEKPY | PhosphoSitePlus | |
| Dephosphorylation site |
| ZN823_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000340683 | Y527C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000340683 | E524Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000340683 | E351K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000340683 | T381A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000340683 | A184S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000340683 | P359A | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000340683 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 18837081 | ENSP00000340683 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Up | 3.8 | 15169874 |
| Hyperphosphorylation site |
| ZN823_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MAPK2_HUMAN | ZN823_HUMAN | kinase -> substrate | RegPhos |
| ST17A_HUMAN | ZN823_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK2_HUMAN | ZN823_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | ZN823_HUMAN | kinase -> substrate | HPRD |
| KS6A2_HUMAN | ZN823_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | ZN823_HUMAN | kinase -> substrate | RegPhos |
| BUB1_HUMAN | ZN823_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | ZN823_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ZN823_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |