| UniProt/SwissProt ID: | DDX25_HUMAN |
| Description: | DEAD (Asp-Glu-Ala-Asp) box helicase 25 [Source:HGNC Symbol;Acc:18698] |
| Location: | chr11 q24.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y113 | LLKGIyAMGFN | DUF1811 | PhosphoSitePlus |
| S369 | QVSLLsGELTV | Helicase_C | PhosphoSitePlus |
| S366 | DGHQVsLLSGE | Helicase_C | PhosphoSitePlus |
| Dephosphorylation site |
| DDX25_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263576 | E178K | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| DDX25_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DDX25_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FRK_HUMAN | DDX25_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | DDX25_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TBK1_HUMAN | DDX25_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK2_HUMAN | DDX25_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | DDX25_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A2_HUMAN | DDX25_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DDX25_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0007286 | spermatid development | IEA | biological_process |
| GO:0005737 | cytoplasm | ISS | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | IEA | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | ISS | molecular_function |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007286 | spermatid development | ISS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0033391 | chromatoid body | ISS | cellular_component |
| GO:0006417 | regulation of translation | ISS | biological_process |
| GO:0006406 | mRNA export from nucleus | ISS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0005634 | nucleus | ISS | cellular_component |
| GO:0006406 | mRNA export from nucleus | IEA | biological_process |
| GO:0033391 | chromatoid body | IEA | cellular_component |
| GO:0005524 | ATP binding | ISS | molecular_function |
| GO:0006417 | regulation of translation | IEA | biological_process |
| GO:0004386 | helicase activity | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |