| UniProt/SwissProt ID: | PIM2_HUMAN |
| Description: | pim-2 oncogene [Source:HGNC Symbol;Acc:8987] |
| Location: | chrX p11.23 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S204 | GTRVYsPPEWI | Pkinase_CAMK | PhosphoSitePlus; SysPTM |
| Y32 | AFEAEyRLGPL | Pkinase_CAMK | PhosphoSitePlus |
| S204 | GTRVYsPPEWI | HPRD; phosphoELM; SysPTM | |
| T195 | HDEPYtDFDGT | HPRD; phosphoELM | |
| T195 | HDEPYtDFDGT | Pkinase_CAMK | PhosphoSitePlus |
| Dephosphorylation site |
| PIM2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000365692 | P252T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000365692 | S276* | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| PIM2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PIM2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PIM2_HUMAN | RBPMS_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | CLASR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | KS6A2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | GCFC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | PUM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | CRK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | BAD_HUMAN | kinase -> substrate | RegPhos |
| PIM2_HUMAN | RMP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | 4ET_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | R3HD2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05221 | Acute myeloid leukemia |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0006468 | protein phosphorylation | ISS | biological_process |
| GO:0008637 | apoptotic mitochondrial changes | IEA | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | ISS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0010508 | positive regulation of autophagy | ISS | biological_process |
| GO:0009615 | response to virus | IEP | biological_process |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0008285 | negative regulation of cell proliferation | IDA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | ISS | biological_process |
| GO:0007140 | male meiosis | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0050821 | protein stabilization | ISS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0000082 | G1/S transition of mitotic cell cycle | IDA | biological_process |