| UniProt/SwissProt ID: | NP1L1_HUMAN |
| Description: | nucleosome assembly protein 1-like 1 [Source:HGNC Symbol;Acc:7637] |
| Location: | chr12 q21.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y110 | KYAVLyQPLFD | NAP | PhosphoSitePlus |
| S242 | SEPDDsDPFSF | NAP | PhosphoSitePlus |
| Y125 | IINAIyEPTEE | NAP | PhosphoSitePlus |
| T64 | LVETPtGYIES | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S143 | EEDEIsEELKE | NAP | PhosphoSitePlus; SysPTM |
| Y377 | ENDPDyDPKKD | PhosphoSitePlus | |
| S237 | TYRMRsEPDDS | NAP | PhosphoSitePlus |
| T62 | DGLVEtPTGYI | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y66 | ETPTGyIESLP | PhosphoSitePlus; HPRD; phosphoELM | |
| Y96 | IEAKFyEEVHD | NAP | PhosphoSitePlus |
| T269 | KGKNVtLKTIK | NAP | PhosphoSitePlus |
| Y106 | DLERKyAVLYQ | NAP | PhosphoSitePlus |
| S143 | EEDEIsEELKE | HPRD; phosphoELM; SysPTM | |
| S10 | DNKEQsELDQD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S69 | TGYIEsLPRVV | PhosphoSitePlus; HPRD; phosphoELM | |
| T39 | KARQLtVQMMQ | PhosphoSitePlus | |
| T31 | ETGEEtKLKAR | PhosphoSitePlus | |
| Y223 | FEPNEyFTNEV | NAP | PhosphoSitePlus |
| Dephosphorylation site |
| NP1L1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376947 | K276Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000376947 | T31K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000376947 | Breast Cancer | Treatment (tamoxifen-sensitive vs. tamoxifen-resistant) | tissue | Down | 0.54 | 19329653 | ENSP00000376947 | Neoplasms by Histologic Type | Cancer vs. Cancer (subtype) | tissue | Up | 3.2 | 16807943 |
| Hyperphosphorylation site |
| NP1L1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M3K7_HUMAN | NP1L1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K4_HUMAN | NP1L1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A2_HUMAN | NP1L1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | NP1L1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NP1L1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042470 | melanosome | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006334 | nucleosome assembly | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0005678 | chromatin assembly complex | TAS | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |