Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RD23B_HUMAN
Description:RAD23 homolog B (S. cerevisiae) [Source:HGNC Symbol;Acc:9813]
Location:chr9 q31.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T159ETPVAtSPTATHPRD
S297IQQNPsLLPALXPC-bindingPhosphoSitePlus
T164TSPTAtDSTSGKAR9PhosphoSitePlus
S160TPVATsPTATDHPRD; phosphoELM; SysPTM
T162VATSPtATDSTKAR9PhosphoSitePlus; SysPTM
S160TPVATsPTATDKAR9PhosphoSitePlus; SysPTM
T164TSPTAtDSTSGHPRD
T155EKPAEtPVATSHPRD; phosphoELM; SysPTM
T159ETPVAtSPTATKAR9PhosphoSitePlus
T155EKPAEtPVATSKAR9PhosphoSitePlus; SysPTM
S166PTATDsTSGDSKAR9PhosphoSitePlus
Y359SGHMNyIQVTPPhosphoSitePlus
T162VATSPtATDSTHPRD; SysPTM

Dephosphorylation site
RD23B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000350708D170NCOSMICSkin Cancer21984974
ENSP00000350708T195ITCGAOvarian Cancer21720365, 18772890
ENSP00000350708T195ICOSMICOvarian Cancer21720365
ENSP00000350708Q293*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000350708Breast CancerMetastasiscell lineUp1.518582095
ENSP00000350708Breast CancerNormal vs. Cancercell lineUp1.520543960
ENSP00000350708Breast CancerNormal vs. Cancercell lineUp1.520543960
ENSP00000350708Breast CancerNormal vs. Cancercell lineUp1.420543960
ENSP00000350708acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.0617655343
ENSP00000350708acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.317655343

Hyperphosphorylation site
RD23B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK38_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANRD23B_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RD23B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071942XPC complexIDAcellular_component
GO:0043161proteasomal ubiquitin-dependent protein catabolic IEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006289nucleotide-excision repairIEAbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0000718nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0000502proteasome complexIEAcellular_component
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0000715nucleotide-excision repair, DNA damage recognitionIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0031593polyubiquitin bindingIDAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0006281DNA repairTASbiological_process
GO:0032434regulation of proteasomal ubiquitin-dependent protIDAbiological_process
GO:0003697single-stranded DNA bindingTASmolecular_function
GO:0007283spermatogenesisIEAbiological_process


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