| UniProt/SwissProt ID: | SIN1_HUMAN |
| Description: | mitogen-activated protein kinase associated protein 1 [Source:HGNC Symbol;Acc:18752] |
| Location: | chr9 q33.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S270 | VEKYSsPGLTS | HPRD | |
| S465 | RRTSFsFQKEK | HPRD | |
| T86 | RRRSNtAQRLE | SIN1 | PhosphoSitePlus |
| S510 | LNRRTsFSFQK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S474 | LNRRTsFSFQK | HPRD | |
| S476 | RRTSFsFQKEK | HPRD | |
| S320 | RRTSFsFQKEK | HPRD | |
| S318 | LNRRTsFSFQK | HPRD | |
| Y497 | TARADyFAQKQ | PhosphoSitePlus | |
| S463 | LNRRTsFSFQK | HPRD | |
| S270 | VEKYSsPGLTS | SIN1 | PhosphoSitePlus |
| S128 | LFEKKsLKEKP | SIN1 | PhosphoSitePlus |
| S512 | RRTSFsFQKEK | PhosphoSitePlus; HPRD | |
| S78 | VEKYSsPGLTS | HPRD | |
| S84 | GIRRRsNTAQR | SIN1 | PhosphoSitePlus |
| Dephosphorylation site |
| SIN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265961 | R81T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000265961 | D376G | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| SIN1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SIN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6A2_HUMAN | SIN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | SIN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SIN1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0048015 | phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008150 | biological_process | ND | biological_process |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0017016 | Ras GTPase binding | NAS | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0006950 | response to stress | IEA | biological_process |