Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CTBP1_HUMAN
Description:C-terminal binding protein 1 [Source:HGNC Symbol;Acc:2494]
Location:chr4 p16.3
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S100IVRIGsGFDNI2-Hacid_dhPhosphoSitePlus
S289EPFSFsQGPLKHPRD
S300EPFSFsQGPLKHPRD; phosphoELM; RegPhos
T144LYRRAtWLHQA2-Hacid_dh; 2-Hacid_dh_CPhosphoSitePlus
S300EPFSFsQGPLK2-Hacid_dh; 2-Hacid_dh_CPhosphoSitePlus
Y370GAAYRyPPGVVHPRD
S158GTRVQsVEQIR2-Hacid_dh; 2-Hacid_dh_CPhosphoSitePlus
S411PPHAPsPGQTVHPRD
S422PPHAPsPGQTVHIPK2RegPhos
Y381GAAYRyPPGVVHPRD
S422PPHAPsPGQTVPhosphoSitePlus; HPRD

Dephosphorylation site
CTBP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000290921P308HCOSMICOvarian Cancer21720365

Differential expressed protein
CTBP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CTBP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK16_HUMANCTBP1_HUMANkinase -> substrateRobert H Newman (2013)
PTK6_HUMANCTBP1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANCTBP1_HUMANkinase -> substrateRobert H Newman (2013)
HIPK2_HUMANCTBP1_HUMANkinase -> substrateRegPhos
CDK4_HUMANCTBP1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANCTBP1_HUMANkinase -> substrateRegPhos
CTBP1_HUMANLEF1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008134transcription factor bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0006098pentose-phosphate shuntIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0008022protein C-terminus bindingTASmolecular_function
GO:0050872white fat cell differentiationISSbiological_process
GO:0007030Golgi organizationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0035067negative regulation of histone acetylationIMPbiological_process
GO:0016616oxidoreductase activity, acting on the CH-OH groupIEAmolecular_function
GO:0017053transcriptional repressor complexIEAcellular_component
GO:0031065positive regulation of histone deacetylationIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0017053transcriptional repressor complexISScellular_component
GO:0019904protein domain specific bindingIPImolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0001106RNA polymerase II transcription corepressor activiIDAmolecular_function
GO:0034401regulation of transcription by chromatin organizatIMPbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0050872white fat cell differentiationIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005634nucleusISScellular_component
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0090241negative regulation of histone H4 acetylationIMPbiological_process
GO:0051287NAD bindingISSmolecular_function
GO:0019079viral genome replicationTASbiological_process
GO:0051287NAD bindingIEAmolecular_function
GO:0070491repressing transcription factor bindingIPImolecular_function
GO:0051726regulation of cell cycleIMPbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0004616phosphogluconate dehydrogenase (decarboxylating) aIEAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0048037cofactor bindingIEAmolecular_function